suicide gene

Relationship between the expression of connexin 43 and bystander effect of suicide gene therapy in ovarian cancer

卵巢癌自杀基因治疗的旁观者效应及其与间隙连接蛋白43表达的关系

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CD/ 5-FC suicide gene therapy system mediated by Bifidobacterium Infantis was noted to have good antitumor effect on melanoma.

婴儿双歧杆菌介导的CD/5-FC自杀基因系统对黑色素瘤具有明显的抑瘤效果。

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At present, the most mature research of suicide gene systems are HSV-TK/ GCV and CD/ 5-FC.

目前研究最为成熟的自杀基因系统是HSV-TK/GCV和CD/5-FC。

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Construction of HSV-tk/ GCV suicide gene system for hepatocarcinoma cells and its bystander effect in rats

大鼠肝癌细胞HSV-tk/GCV自杀基因系统的构建及其旁观者效应

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Bystander effect in suicide gene therapy for glioma

恶性胶质瘤自杀基因治疗中旁效应的机理

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Killing Effect of Human Pulmonary Adenocarcinoma Cells with TK+ CD/ 5-Fc+ GCV Coexpression Suicide Gene Systems

自杀基因CD、TK的共表达对人肺腺癌细胞的杀伤作用

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Research and progress on suicide gene therapy for pancreatic tumor

自杀基因在胰腺癌治疗中的研究进展

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Investigate the Synergy of Liu Wei Di Huang Bolus on Hepatocarcinoma Suicide Gene Therapy from Gap Junction

从缝隙连接探讨六味地黄丸对自杀基因治疗肝癌的增效作用

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The gene deletion technique include transposition bracketing method and the construction of suicide plasmid.

其中基因缺失技术还包括转座子插入法和自杀性质粒的构建。

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Conclusion DAAO/ D Ala suicide gene system might be useful in cancer gene therapy.

结论DAAO D Ala自杀基因系统可以进一步用于肿瘤的基因治疗研究。

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Suicide gene therapy, also known as gene-directed enzyme prodrug therapy, is an important strategy for tumor treatment by improving the specifical concentrations of drugs in tumors and a unique bystander effect.

自杀基因疗法，又名基因介导的酶-前药疗法，能特异性提高药物在肿瘤中的浓度，并具备独特的旁观者效应，是肿瘤基因治疗的重要方法之一。

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Suicide gene therapy for glioma using HSV tk/ GCV system

HSV-tk/GCV系统对神经胶质瘤的自杀基因治疗研究

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The Enhancing Utility and Mechanism Research of Curcumin on Bystander Effect of HSV-tk/ GCV Suicide Gene System

姜黄素对tk/GCV自杀基因系统旁观者效应的增效作用及机制

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Killing effect of GCV combined with suicide gene HSV-tk on human osteosarcoma cells in vitro

HSV-tk/GCV自杀基因系统对骨肉瘤细胞体外杀伤效应

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Thereby, it was suggested that optimal gene therapeutic model might enhance the curative effect of suicide gene.

提示：优化胶质瘤基因治疗模式可进一步提高基因治疗效果。

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Experimental Study on Colorectal Carcinoma Associate Double Suicide Gene Therapy with Radiotherapy

双自杀基因联合放疗对大肠癌治疗的实验研究

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Conclusion HSV-TK/ GCV in combination with HCPT can enhance the lethal effect of suicide gene therapy against human bladder carcinoma cells and effectively induce apoptosis of the cells.

结论HSV-TK/GCV系统联合HCPT治疗能增强自杀基因系统对人膀胱癌的杀伤作用，能够良好地诱导人膀胱癌细胞的凋亡。

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Effects of CD/ 5-FC suicide gene therapy system on human malignant glioma cells in vitro

CD/5-FC自杀基因治疗系统体外杀伤恶性人脑胶质瘤细胞作用的研究

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The development of herpes simplex virus thymidine kinase suicide gene imaging

单纯疱疹病毒胸苷激酶自杀基因显像研究进展

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Therefore enhancing the bystander effect has become an important strategy to raise curative effect of the suicide gene therapy.

因此，增强旁观者效应已成为提高肿瘤自杀基因治疗疗效的重要策略。

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Conclusion Recombinant Bifidobacterium Infantis with UPRT gene can significantly enhance the killing effect of CD/ 5-FC suicide gene system on melanoma B16-F10 cells of mice.

结论婴儿双歧杆菌联合转导UPRT基因可明显增强CD/5-FC自杀基因系统对鼠黑色素瘤细胞B16-F10的杀伤作用。

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Experimental studies of using adenovirus-mediated cd/ 5-fc suicide gene in treatment of pan-creatic cancer

CD/5-FC自杀基因系统治疗胰腺癌的实验研究

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Objective: To explore therapeutic effect of a novel yeast cytosine deaminase ( YCD) suicide gene in vivo on P388/ DBA murine leukemia model.

目的：以P388/DBA小鼠白血病模型，探讨新型自杀基因YCD的体内治疗作用。

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Followed the prodrug fludarabine incubation, the cytotoxic effect, bystander effect and apoptosis induction of PNP/ fludarabine suicide gene system on BEL7402 cells were detected by methyl thiazolyl tetrazolium ( MTT) colorimetric method and Annexin V-FITC apoptosis detection kit, respectively.

分别应用四甲基偶氮唑蓝（MTT）比色法和Annexin V鄄FITC凋亡检测试剂盒检测PNP/fludarabine自杀基因系统对BEL7402细胞的细胞毒效应、旁观者效应和诱导凋亡作用。

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Synergism of Liuwei Dihuang Bolus on Suicide Gene Therapy for Murine Transplanted Hepatocarcinoma

六味地黄丸对小鼠移植性肝癌自杀基因治疗的增效作用

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Experimental Study on Treatment of Colon Cancer with E. Coli. Cytosine Deaminase Suicide Gene

胞嘧啶脱氨酶自杀基因治疗大肠癌的实验研究

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The suicide gene system has almost the bystander effect, but its mechanism has yet been unclear.

现已证明，几乎所有的自杀基因系统都具有旁观者效应，但其作用机制尚不十分清楚。

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Enhancing Effect of Chinese Herbal Medicine Active Components on Suicide Gene Bystander Effect and the Mechanism Study

中药活性成分对自杀基因旁观者效应增效作用及机制研究

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