Reversal of multidrug resistance and its mechanism by tetramethylpyrazine

1、

BACKGROUND OBJECTIVE: Multidrug resistance of tumor cells often leads to failure of chemotherapy. The over expression of P glycoprotein ( P gp), encoded by multidrug resistance 1 ( mdr1) gene, plays an important role in multidrug resistance of breast cancer.

背景与目的：肿瘤的多药耐药性常导致乳腺癌化疗失败，多药耐药基因1（Multidrug Resistance1，mdr1）编码的P-糖蛋白（P-glycoprotein，P-gp）过度表达是重要的耐药机制。

互联网摘选

2、

Due to the complexity of tumor formation mechanism and the existence of multidrug resistance, it will not kill the tumor cells completely by using one drug alone.

但由于参与肿瘤形成的分子生物学机制的复杂性和多样性，以及肿瘤细胞多药耐药性的产生，使得仅仅利用一种化疗药物无法从根本上杀灭肿瘤细胞。

互联网摘选

3、

Study on tumor cells' multidrug resistance and its reversion by Chinese herbs

肿瘤多药耐药性与中药逆转研究

互联网摘选

4、

Progress in the study of drug delivery system based on nanoparticles to overcome multi-drug resistance

纳米粒给药系统逆转肿瘤多药耐药性的研究进展

互联网摘选

5、

Study on Active Constituents of Traditional Chinese Medicine Reversing Multidrug Resistance of Tumor Cells in vitro

中药活性成分体外逆转肿瘤细胞多药耐药性的研究

互联网摘选

6、

Conclusions: the multidrug resistance characteristic in SGC-7901/ 5-FU resistant cells may be related to micro-RNA expression profile changes, providing a new research direction to solve the multidrug resistance of tumor chemotherapy.

结论：SGC-7901/5-FU耐药细胞的多药耐药特性可能与micro-RNA表达谱的改变有关，为解决肿瘤化疗的多药耐药性提供新的研究方向。

互联网摘选

7、

Advances of study on tumor multi-drug-resistance and reversal agents

肿瘤多药耐药性及其逆转剂研究进展

互联网摘选

8、

Analysis of bacterial type, drug resistance and infection related factor of multi-drug resistant strains of nosocomial infection in ICU patients

ICU医院感染多重耐药菌类型、耐药性及感染相关因素研究Necroptosis克服肿瘤多药耐药性

互联网摘选

9、

Construction of Magnetic Nano-antisense Probe Using for Tumor Multidrug Resistance

肿瘤多药耐药性磁性纳米反义探针的构建

互联网摘选

10、

Tumor multidrug-resistance and reversing actions of traditional Chinese medicine

肿瘤细胞多药耐药性与中药的逆转作用

互联网摘选

11、

The Involvement and Modulation of ABC Transporters in Multidrug Resistance

肿瘤多药耐药性中的ABC转运蛋白及其调节

互联网摘选

12、

Expression of glucosylceramide synthase mRNA in vincristine-resistant KBV_ ( 200) cell line in association with multidrug resistance

葡萄糖神经酰胺合酶基因在多药耐药肿瘤细胞株KBV（200）的表达及其与肿瘤多药耐药性的关系

互联网摘选

13、

lord harris of high cross, economist and freedom-fighter, died on october 19th, aged 81

中立议员哈里斯爵士，一名经济学家，为自由而战的斗士，于十月十九日逝世，享年八十一岁

互联网摘选

14、

effect of high cross-linking on noncrystallization of corn starches

高交联玉米淀粉的非晶化特性

互联网摘选

15、

study on synthetic technology of high cross-linked potato starch

高交联度马铃薯淀粉合成工艺研究

互联网摘选

16、

study on the properties of physical state of high cross - linked and non - gelatinized starches by dsc

用差示扫描量热法研究高交联非糊化淀粉的物态性质

互联网摘选

17、

three dimensional finite element analysis on thermal force coupling concerning three -high cross -rolling process with round billet

圆坯三辊斜轧过程的三维有限元热-力耦合分析

互联网摘选

18、

we are sorry to report that ralph harris (lord harris of high cross) died of a suspected heart attack at 8am this morning.

拉尔夫哈里斯，今早八时，疑似死于心脏病。对此我们深表遗憾。

互联网摘选

19、

but lucy tusting says it is not easy to decide whether to use the method. she says these methods have been a major reason for the successes in malaria control in recent years.

但是露西塔斯汀表示决定是否使用该方法并非易事。她说这些方法是近年来疟疾防控取得成效的主要原因。

互联网摘选

20、

in the city, efforts will be made to set up and improve the security system including the old-age insurance, medicare insurance, unemployment insurance, and child-bearing insurance.

在城市，建立健全养老保险、医疗保险、失业保险、生育保险等保障制度。

provided by jukuu