FMOC

Fmoc Solid-phase Synthesis of Thymosin α 1

胸腺素α1的Fmoc固相合成法

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After each round of coupling we used the ninhydrin method to examine the condensation degree and determined the peptide coupling rate by measuring the absorbance of the Fmoc group.

每一轮反应后都使用茚三酮法检验缩合完成程度，并通过测定缩合肽链上的Fmoc基团吸光度确定肽键缩合率。

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Study on Fmoc solid-phase synthesis and activity of thymosin α_1

人胸腺肽α1的固相合成及体外活性研究

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FMOC has been used to the automatic train control and its feasibility and superiority have been proved by the simulation results.

将FMOC用于列车运行控制的仿真，结果证明了它的适用性。

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The coupling reaction between the difficult sequence Fmoc-Arg ( Pbf )-OH and H-Pro-Trt resin was investigated.

着重研究了 Fmoc -Arg ( Pbf ) -OH与H -Pro-Trt 树脂的缩合反应.

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Directly Synthesize A β_ ( 1-15) Peptide Vaccine by Fmoc Solid-phase Peptide Synthesis and Study Its Immune Activity

Fmoc固相直接法合成Aβ（1-15）肽疫苗及其免疫活性

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Results The Fmoc protected PNA monomer and the key component isocyanide were synthesized;

结果合成了Fmoc保护的PNA单体和关键组分异腈。

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The synthesis of cyclo (-Ab 7-Aib-Phe-D-Pro-) which uses solid phase peptide synthesis with N-Fmoc protection is faild.

本论文尝试用固相法氨基酸N端Fmoc保护策略合成cyclo ( -Ab7-Aib-Phe-D-Pro- ).但是最终产物经ESI-MS分析不是目标产物,故改用液相法合成目标化合物.

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And the L-Lys containsside chain ammonia , the protected product is Fmoc-L-Lys ( Boc ).

含侧链氨基的L - 赖氨酸, 所合成的正交保护的L - 赖氨酸是 Fmoc -L-Lys ( Boc ).

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Firstly, Fmoc Gly OH reacted with DCC, and DMF was added for the dissolution of the precipitated product, and secondly DMAP was added for the esterification of activated Fmoc Gly OH with Wang resin to prepare Fmoc Gly Wang resin.

Fmoc-甘氨酸首先与DCC反应，然后加入DMF使反应中产生的沉淀溶解，再加入DMAP催化，使活化的Fmoc-甘氨酸与羟基树脂缩合，生成Fmoc-甘氨酸-王氏树脂。

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Synthesis of Fmoc-Asn ( Trt)-Wang resin

Fmoc-Asn（Trt）-Wang树脂的合成研究

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Methods Ugi four component condensation reaction ( Ugi 4 CC) was used to synthesize PNAs, in which the Fmoc protecting strategy was adopted;

方法采用Ugi四组分缩合反应进行PNA单体的合成并采用Fmoc的保护策略。

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The esterification process of Fmoc-Asn ( Trt )-OH and Wang resin was studied by solid phase synthesis.

研究了 Fmoc -Asn ( Trt ) -OH与Wang树脂的酯化反应工艺.

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In the preparation of Fmoc-Gln ( Trt)-OH, we adopted acetone as solution to increase the yield and reduce the cost.

在Fmoc-Gln（Trt）-OH的制备过程中，我们用丙酮作溶剂，大大降低了成本，也得到了较高的产率。

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Fmoc, Boc and Pbf were used respectively to protect α-amido, side amido and side guanidine group.

对于α-氨基仍采用Fmoc保护策略, 侧链氨基用二碳酸二叔丁酯引入叔丁氧羰基来保护,侧链胍基用酸敏感保护基2,2, 4,6,7-五甲基二氢苯并呋喃-5-磺酰基来保护.

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Study on Artwork of Fmoc Solid-Phase Synthesis of AN-M Identification and Analysis of Polypeptides by Electrospray Ionization Tandem Mass Spectrometry

固相法合成多肽AN-M的工艺研究合成多肽的电喷雾质谱研究

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Determination of Alendronate Sodium Tablets and Its Related Substances 4-Aminobutyric by HPLC Pre-column Derivatization with FMOC

FMOC柱前衍生化HPLC法测定阿仑膦酸钠片含量及有关物质4-氨基丁酸

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Osteogenic growth peptide ( OGP) has been synthesized through Fmoc solid phase synthesis procedure. The purity of synthetic OGP ( sOGP) is over 98.6% identified by HPLC, the amino acid sequence and electro-spray mass spectroscopy are consistent with theoretical values.

Fmoc法固相合成成骨生长肽（sOGP），HPLC鉴定纯度大于98.6%，质谱测定，分子量1523.5kD，与理论分子量相符，N端全序列测定结果正确。

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A novel disulfide bond-bearing cyclopeptides has been designed and synthesized by means of air oxidation of bis ( S-Acm) which was synthesized through Fmoc solid-phase synthesis.

采用Fmoc固相合成法得到直链肽，通过空气氧化两个半胱氨酸的巯基生成二硫键，得到一类新型含二硫键的环肽。

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Synthesis of fmoc-chloride by diphosgene method

双光气法合成氯甲酸-9-芴甲酯

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Fmoc solid-phase synthesis of MSH peptide

Fmoc固相合成法合成黑色素细胞刺激素（MSH）的工艺研究

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Two biotin containing lysine derivatives, Boc Lys ( Biotin) OH and Fmoc Lys ( Biotin) OH were synthesized starting from lysine.

以赖氨酸为原料，合成了两种含生物素的赖氨酸衍生物Boc-Lys（Biotin）-OH和Fmoc-Lys（Biotin）-OH。

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Methods: The mole ratio of Fmoc Gly OH: DCC: DMAP: Wang resin was 10 ∶ 5 ∶ 1 ∶ 1, reaction time was 1 5h in this procedure.

方法：采用Fmoc-甘氨酸：DCC：DMAP：王氏树脂的摩尔比为10：5：1：1，反应时间1.5h。

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Studies of esterification of Wang resin and fmoc/ tbu tyrosin in solid phase peptide synthesis

固相多肽合成中王树脂和Fmoc/tBu酪氨酸成酯反应的研究

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Methods Peptides were synthesized by Fmoc chemistry method.

方法采用标准Fmoc法人工合成RDP1258。

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