therapeutic window

Conclusions The potential thrombolytic therapeutic time window in rats is 6~ 12 hours after MCAO.

结论大鼠大脑中动脉闭塞后，潜在的最长溶栓治疗时间窗为6～12h。

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RESULTS: It was found that first time performed TDM data within therapeutic window only took up 40.7%.

结果：首次治疗药物监测（TDM）结果在有效治疗窗内的仅占40.7%；

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Therapeutic window of whole-blood sirolimus concentration in kidney transplantation recipient

肾移植受者应用西罗莫司治疗窗的临床研究

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AIM: To study the therapeutic window of sirolimus concentration in Chinese kidney transplantation recipient.

目的：探讨西罗莫司应用于国内肾移植受者的治疗窗范围。

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Objective To study the curative effect and safety of thrombolytic therapy with broadened therapeutic window for cerebral infarction.

目的对超过溶栓治疗时间窗的病人，作静脉溶栓疗效和安全性的初步探讨。

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Considering the narrow therapeutic window of oncolytic drugs, this CAM use increases the risk of clinically relevant herb-anticancer drug interactions, therefore leading to substantially more unexpected toxicities of chemotherapeutic drugs and possible undertreatment seen in cancer patients.

由于抗肿瘤药物的治疗窗通常都比较狭窄，中药的合用增加了临床上中西药发生相互作用和不良反应的风险，导致化疗药物对病患疗效不佳或产生毒性反应。

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Discussion on Therapeutic Window Concentration of Digoxin

地高辛治疗窗浓度的再探讨

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Results: Among 331 cases, serum concentrations of 236 cases were within the therapeutic window, taking 71.3% with an effective rate of 93.0%.

结果：331例血药浓度监测中，丙戊酸血清药物浓度位于治疗窗内236例，占71.0%，有效率93.0%；

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In this summary, we overview the development of conditioned use of broadened therapeutic time window nowadays, to discuss how to extend TTW in order to make more patients benefit.

本文总结当前国内外拓宽溶栓时间窗在急性缺血性脑卒中治疗的新进展，以探讨如何延长治疗时间窗，使更多的患者得到有效治疗。

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A lot of researches showed that strychnine and brucine have a wide of pharmacological activities, but they also have considerable toxic. Strychnine and brucine belong to the drugs of narrow therapeutic window, litter change on the concentration may cause the poison.

大量的研究表明，马钱子碱和士的宁具有广泛的药理作用，但是它们也具有相当大的毒性，均属于治疗浓度窗很窄的药物，浓度的稍微改变便可能引起药效的改变甚至中毒。

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Therapeutic Window Concentration of Tacrolimus: Survey of 56 Cases of Renal Transplant Recipients

56例患者肾移植术后他克莫司治疗窗浓度范围再探讨

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Monitoring of Peak Blood Concentration in Renal Transplant Recipients 2h after Oral Administration of Cyclosporine A and Study on Therapeutic Window Concentration

肾移植术后服用环孢素A2h血药浓度峰值监测及治疗窗浓度探讨

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Objective: To discuss the existence and significance of therapeutic window in hypoxic-ischemic cerebral damage ( HIBD) in piglets.

目的探讨新生猪缺氧缺血性脑损伤（HIBD）治疗时间窗的存在及其意义。

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To expand the therapeutic window, more efforts have been taken to the alternative treatment, including cell transplantation, which has been greatly boosted by the development of stem cell research and application.

为了扩大脑中风的治疗窗，医疗科研人员努力寻求新的治疗方式。其中细胞移植治疗发展迅速，这与干细胞研究及应用的飞速发展密切相关。

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From our research, we come to the conclusion that the dose threshold and therapeutic window can be appropriately broadened on basis of Chinese Pharmacopoeia.

从本课题研究中可以看出，以上所选十五味药物的剂量阈和治疗窗（在汤剂中的成人一日服用量）在《中国药典》法定药物剂量范围的基础上可适当放宽。

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Do you think the result of EPITHET trial has enough power to change the current therapeutic window for intravenous thrombolysis?

您认为EPITHET试验的结果是否会改变静脉溶栓的治疗窗？

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Conclusion: Thrombolytic therapy with broadened therapeutic window for acute cerebral infarction with low dose urokinase is beneficial and safe.

结论：小剂量尿激酶超时间窗治疗急性脑梗死安全有效。

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Therapeutic window of mild hypothermia for cerebral middle artery occlusion: the effect of onset of mild hypothermia on infarction volume

实验性脑梗死的亚低温治疗时间窗&亚低温开始时间对脑梗死体积的影响

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Early therapeutic window of clozapine side effect

氯氮平的早期副作用治疗窗

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Conclusion: 1H-MRS can provide information about metabolic changes that may be useful for prediction of therapeutic time window of cerebral infarction.

结论：1H-MRS所提供的脑梗死区代谢变化对脑梗死救治时间窗口的预测可能有一定帮助。

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Clinical study of small dose urokinase for post therapeutic window of UK thrombolysis of cerebral infarction by interventional pressor perfusion

错过溶栓时间窗的脑梗死通过动脉介入加压灌注治疗临床探讨

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Preliminary establishment of the therapeutic window concentration of tacrolimus in liver transplant recipients

肝移植受者他克莫司治疗窗浓度的初步确定

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Therapeutic window of insulin treatment for cerebral ischemic-reperfusion injury in rats

大鼠全脑缺血再灌注后胰岛素的治疗时间窗

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50 cases of serum concentration were below the therapeutic window, taking 15.1% with an effective rate of 12.0%.

低于治疗窗50例，占15.0%，有效率12.0%。

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Establishment of therapeutic window for digoxin in different kinds of patients

不同类型患者地高辛治疗窗的确定

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45 cases of serum concentration were above the therapeutic window, taking 13.6% with an effective rate of 91.0%.

高于治疗窗45例，占14.0%，有效率91.0%；

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Aim To monitor the whole blood trough concentration of cyclosporine A ( CsA) in renal transplant recipients, and to suggest optimal therapeutic window of CsA.

目的通过监测肾移植后病人环孢素A（CsA）全血浓度，提出CsA在三联免疫抑制用药方案中的理想治疗窗。

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CONCLUSION: Within the above therapeutic window concentration range, CsA is of ideal immuno-suppressive action meanwhile it can less rejection and minimize the hepatic and renal drug toxicities.

结论在上述治疗窗浓度范围，CsA既能达到满意的免疫抑制效果，又能减少排斥反应和肝、肾毒性的发生。

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Intervence measures of multiple targets, levels and pathways within "the therapeutic window" are very important for recovery of disease.

在有效“时间窗”内采取多靶点、多水平、多通道的干预措施，对疾病的转归至关重要。

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Objective: To investigate the therapeutic window of mild hypothermia on cerebral infarction.

目的：确定脑梗死亚低温治疗的时间窗。

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