neurofibrillary

The pathological changes of brain, such as neurofibrillary tangle ( NFT) and senile plaque ( SP), were observed by using HE staining and Bielschowsky staining.

苏木精-伊红染色观察神经细胞形态和数量，Bielschowsky染色观察神经元纤维缠结（NFT）和老年斑等病理改变。

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Definitie diagnosis requires postmortem identification of amyloid plaques and neurofibrillary tangles linked to the disease.

最终确诊需要尸检发现与本病相关的淀粉样蛋白斑及神经纤维缠结.

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Neuritic plaques ( NPs) and neurofibrillary tangles ( NFTs) are the two most characteristic pathologic hallmarks of AD.

神经炎性斑块和神经纤维缠结是AD主要的病理学特征。

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The mainly pathological changes in AD included senile plaque formed with A β deposition, neurofibrillary tangles ( NFTs), synapses loss and neural cell death.

AD的病理变化主要是β淀粉样蛋白（Aβ）沉积造成的老年斑、神经纤维缠结、突触丢失和神经元死亡。

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The main histopathological hallmarks of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles ( NFTs) in brain cortex, and decrease of brain cortex cells.

AD的特征性病理学改变为大脑皮质神经细胞内神经原纤维缠结、细胞外大量老年斑形成和大脑皮质细胞减少。

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The characteristic change of pathology in AD were neuritic plaques ( NP), neurofibrillary tangles ( NFTs) and the loss of cholinergic neuron.

主要的病理改变为神经炎斑，神经纤维缠结，胆碱能神经元丢失等。

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In Non-gmo models most only simulate a certain aspect of AD pathology characteristics, while the pathological process of AD is complex, various, and do not present the AD typical characteristic in the brain: senile plaques ( SP) and neurofibrillary tangles ( NFTs).

非转基因模型中，大部分模型只针对AD病理特征的某一个方面，而AD的病理过程是复杂的多方面的，且不呈现AD脑内特征性改变：SP和NFTs。

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Human apoE 4 has been found in senile plaques ( SPs ) and neurofibrillary tangles ( NTFs ) in AD brains.

研究进一步表明,AD患者脑内的老年斑和神经原纤维缠结中存在有较多的载脂蛋白E4 ( apolipoproteinE4, apoE4 ).

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Toxications of the central nerve system include impairment of learning and memory, neurofibrillary tangles ( NFTs) in different brain tissues, increasingly gathered aluminum in the brain and the functional decrease of the central cholinergic nerve.

其对中枢神经系统的毒性作用可引起学习记忆障碍，引起脑内多种组织出现神经纤维缠结，且脑组织铝含量明显升高，同时脑内胆碱能神经功能明显降低。

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