1、

Bone resorptive function is resulting from the activation of osteoclast. Therefore, osteoclasts play a key role in bone formation and bone mass regulation.

骨吸收作用是通过破骨细胞的活动完成的,因此,破骨细胞在骨骼的形成和骨量的调节方面起着关键作用。

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Results: VEGF and CD34 were expressed in all cases of GCT investigated. VEGF was presented in spindle shaped stromal like tumor cells and osteoclast like multinucleate giant cells.

结果:VEGF在40例GCT中,无论是梭形的基质细胞,还是多核巨细胞均有表达,Ⅲ期的骨巨细胞瘤VEGF的表达明显高于第Ⅰ/Ⅱ期的GCT;

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osteoclasts are a kind of multinucleated giant cell derived from monocyte/ macrophages line, capable of bone absorption. the level of rank expression in the cell line indicated the potential of monocyte/ macrophages differentiating into osteoclast-like cells.

破骨细胞是负责吸收骨质的多核巨细胞,主要来源于单核/巨噬细胞系,该细胞系RANK表达的多少在某种程度上体现了单核/巨噬细胞向破骨细胞样细胞分化的潜能。

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When activated by maturation factors including VEGF, the pre-osteoclasts differentiated into mature osteoclasts and chew up bone tissue, providing the tumor new space to grow.

一旦由包括VEGF在内的促成熟细胞因子活化后,破骨细胞的前体细胞可以分化成为成熟的破骨细胞,破坏骨组织,给肿瘤细胞的生长腾出空间。

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Effects of Salvia Miltiorrhiza Bung on osteoclast like cells formation in mouse bone marrow culture

丹参对骨髓培养中破骨细胞生成的影响

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Conclusion: BYD could significantly inhibit the activity of osteoclast.

结论:补肾益精方具有明显的抑制破骨细胞活性的作用。

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Results Large multinucleated TRAP-positive osteoclasts from cortical bone were cultured. No obvious effect of icaritin on mature osteoclast was observed.

结果皮质骨内层可培养出多核、体积大、抗酒石酸酸性磷酸酶(TRAP)染色阳性的破骨细胞,淫羊藿提取物对皮质骨来源的破骨细胞没有明显影响。

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Conclusion Highly purified CD68+ cells can be obtained from human PBMCs as the osteoclast precursors, and mature osteoclasts can be induced from CD68+ mono/ macrophages by RANKL.

结论人外周血单核细胞中CD68+细胞是破骨前体细胞,在RANKL在诱导下分化为成熟破骨细胞。

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9、

Effects of combination of bone protectin and alendronate on differentiation of osteoclast precursors

联合应用骨保护素和阿伦膦酸钠对破骨前体细胞分化的影响

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influence of drynaria rhizome on culture in vitro of marrow osteoclast in rat

中药骨碎补对大鼠骨髓破骨细胞体外培养的影响

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11、

effects of mechanical stress on osteoclast protein expression-a proteomic study; tractor-drawn centrifugal spreader

机械性牵张力在破骨细胞形成过程中作用的差异蛋白质组学研究机械牵引离心式撒肥车

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Undifferentiated carcinomas with osteoclastic-like giant cells carry a similar prognosis to ductal adenocarcinoma.

伴有破骨细胞样巨细胞的未分化癌与导管腺癌有相似的预后.

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Immunohistochemistry, the osteoclast-like giant cells were positive for CD 68. Vim, α1-ACT and negative for CK, EMA.

免疫表型: 破骨细胞样巨细胞CD68、Vim 、 α 1ACT 均阳性,ck 、 EMA均阴性.

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Its differentiation effect on inhibiting osteoclast was assessed with statistics analysis.

统计学分析评价其抑制破骨细胞分化效果.

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Object : The study a feasibility method of obtaining human osteoclast-like cells for purpose of further research.

目的: 探讨可行的获取人破骨细胞样细胞以供进一步研究的方法.

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The purified protein has been used for induced osteoclast differentiation in vitro.

纯化蛋白,体外诱导破骨细胞分化.

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Frequent osteoclast-like giant cells are present.

常见破骨样巨细胞.

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18、

Osteoblast and osteoclast activity in a malignant infantile osteopetrosis patient following bone marrow transplantation.

骨髓移植之后的恶性婴儿骨硬化病的成骨细胞和破骨细胞活性.

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Until now, the mechanism to control osteoclast division, growth, move and function and death is still not clear.

迄今为止,控制破骨细胞分化、成熟、迁移、发挥功能及凋亡的确切机制仍不清楚。

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The experiments prove the establishment of the system can be trained induction of success with bone absorption function of the osteoclast.

证明本次实验建立的共培养体系可以成功诱导出具有骨吸收功能的OC。

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