lactacystin

Effects of Lactacystin on the Expressions of Gene and Protein of Tyrosine Hydroxylase

Lactacystin对酪氨酸羟化酶基因和蛋白表达的影响

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Conclusion The rat model of Parkinson's disease with Lewy body is set up by using Lactacystin which can block the α-synuclein degradation.

结论利用蛋白酶体抑制剂Lactacystin阻碍α-synuclein的降解可以建立有Lewy体的PD大鼠模型。

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Experimental study of Parkinson ′ s disease rats induced by lactacystin

乳胞素诱导大鼠致帕金森病的实验研究

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Applying Lactacystin, a selective proteasome inhibitor, to set up the rat model of Parkinson's disease with Lewy body

应用蛋白酶体抑制剂Lactacystin建立有Lewy体的帕金森病大鼠模型

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Aim : To study the effect of lactacystin on dopamine ltransporter ( DAT ) and vesicular monoamine transporter ( VMAT 2 ) protein expressions in rats striatum.

目的: 探讨蛋白酶体抑制剂lactacystin对大鼠纹状体多巴胺转运体 ( DAT ) 和囊泡单胺转运体2 ( VMAT2 ) 蛋白表达的影响.

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PD rats that expressed Lewy body and presented lateral rotation were made by injecting 8 μ g lactacystin into one side of substantia nigra compact part of rat with stereotaxic technique.

在大鼠单侧黑质致密部（SNc）立体定向注射蛋白酶体抑制剂lactacystin8μg，建立表达Lewy小体并向偏侧旋转的PD大鼠。

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Synergistic Toxic Effect of Paraquat and Lactacystin on Substantia Nigra

百草枯与lactacystin对黑质细胞协同毒性作用

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Conclusion: There is synergistic toxic effect between lactacystin and paraquat and the chronic exposure to paraquat can increase the risk for PD of rats with lightly impaired proteasome.

结论：lactacystin与PQ之间存在协同作用，长期小剂量PQ的暴露能显著增加蛋白酶体功能轻微损害的大鼠患PD的风险。

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