objective to investigate the effects of keratinocyte growth factor ( kgf) and kgf receptor ( kgfr) antisense oligonucleotide ( asodn) on cell cycle and apoptosis of hacat cells.

conclusion kgf possesses the effect of improving the proliferation of iec 6 and its radioprotective effect might be due to the decrease of cell radiation sensitivity and the inhibition of the apoptosis of radiation reduced cells.

结论KGF具有促肠上皮细胞增殖作用，其辐射防护作用表现为降低细胞辐射敏感性，抑制辐射诱导的细胞凋亡可能是其作用机制之一。

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skin damage repairing is a very complicated process, which is mediated by a variety of growth factors and cytokines. among those factors, keratinocyte growth factor ( kgf) play a more important role.

皮肤损伤的修复是-个非常复杂的过程，由多种生长因子及细胞因子介导，其中角质细胞生长因子（KGF）发挥了重要的作用。

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results the kgf and kgfr genes were expressed in the hela cells. the kgf and kgfr proteins were expressed in the hela cells.

结果①从基因水平和蛋白水平证实KGF及KGFR在Hela细胞中有表达。

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radiation can induce expression of c-fos and kgf in skin of filial mice. intensity of the expression relate to dosage and time of radiation and the radiation sensitivity of tissue.

辐射能诱导皮肤组织中c-Fos，KGF的表达，其表达强度与辐射剂量、时间及组织辐射敏感性有关。

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kgf is not only the mitogen of epithelial cells, but also the cytokine, which can enhance regeneration and sodium-water transport of alveolar epithelial cells.

KGF不仅是上皮细胞的丝裂原也是促进肺泡上皮细胞的钠水转运和再生的因子。

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results showed that the topical application of kgf could accelerate wound healing: the wound area of treated group was smaller than the control one at the same time after scalded;

结果表明，用药后，小鼠伤口愈合较快，在伤后的同一时间，用药组的伤口面积小于对照组；

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conclusion kgf and ngf may play an important role in the hyperplasia and differentiation of keratinocyte in psoriasis; ngf also mediate inflammatory and immunity reaction.

结论KGF、NGF对银屑病表皮中的角质形成细胞的增生、分化均有重要的作用，而NGF还可以介导炎症反应及免疫反应。

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results: kgf gene was expressed in cos7 and kgf was able to stimulate iec_6 cells.

结果：KGF基因在COS7中得到了表达，并对小鼠肠上皮细胞（IEC6）具有刺激增殖作用。

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apoptosis, proliferation and differentiation of alveolar epithelial cells and protective effects of kgf on premature rats with hyperoxia-induced cld

高氧致CLD早产鼠肺泡上皮细胞凋亡、增殖和分化的动态变化及KGF对其调节作用研究

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conclusion the results suggest that exogenous kgf stimulate proliferation of human corneal epithelial cells and accelerate corneal epithelial wound healing in vivo.

结论外源性KGF对体外培养的人角膜上皮细胞有明显的促生长作用，其滴眼液有加速兔眼角膜上皮创伤修复的作用。

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results: the expression levels of kgf in prostatic carcinoma tissues were higher than those in normal prostate tissues ( p < 0.05).

结果：前列腺癌组织中的KGF表达高于正常的前列腺组织（P

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methodology: the proliferative effect of kgf on cyst-lining epithelia was assessed by mtt assay.

方法：应用MTT法检测KGF对ADPKD囊肿衬里上皮细胞的促增殖作用；

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relationship between the mrna transcriptions of bfgf and kgf in the carcinogenesis of oral mucosa

bFGF及KGF的mRNA的表达与口腔粘膜上皮癌变的关系

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objective to study radioprotective effect and the mechanism of keratinocyte growth factor ( kgf) on irradiation induced intestinal epithelial cell line no.

目的探讨角质细胞生长因子（KGF）的辐射防护作用与机制，为应用KGF防护肠道辐射损伤提供实验依据。

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the above findings suggested that kgf may contribute to the formation and development of renal cyst in adpkd.

这些结果充分表明了两株细胞存在极大的生物学差异，提示KGF在ADPKD囊肿形成和发展中具有明显的作用。

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objective: to demonstrate changes of kgf in premature rats with hyperoxia-induced cld.

目的探讨高氧致CLD早产大鼠KGF表达的变化规律。

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kgf expression was detected by immunohistochemistry.

免疫组化检测KGF表达。

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the effect of kgf on cyst-lining epithelia cell cycle were observed by flow cytometer.

应用流式细胞仪观察KGF对ADPKD囊肿衬里上皮细胞细胞周期的影响；

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the hela cells were stimulated to proliferate by the recombinant human kgf.

人重组KGF因子对Hela细胞有明显的增殖作用。

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conclusion: kgf is hopeful to be a new therapeutic drug for intestinal type of radiation damage.

结论：KGF有望成为肠型放射病治疗的新型药物。

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