effect of butylphthalide on the expression of s100 in alzheimer model rats

1、

nbp obviously inhibited transient focal cerebral ischemia induced apoptosis in cortex and striatum, decrease the activation of caspase-9, block activation of caspase cascade and relieve neuronal injury.

丁苯酞对脑缺血再灌注引起的皮层和纹状体的神经细胞凋亡有明显抑制作用，可抑制脑组织凋亡调节蛋白Caspase-9的表达，从而阻断了caspase的始动激活，减少神经元的损伤和凋亡。

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2、

conclusion oxiracetam was effective to improve brain function of patients with acute mild head injuries, its effect is better than that of pivecetam.

结论奥拉西坦能显著改善急性轻型脑伤患者的脑功能，其作用强于吡拉西坦。

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3、

objective to study the effect of oxiracetam on the current of sodium and potassium channels in rat hypothalamic neurons.

目的研究在奥拉西坦作用下大鼠下丘脑神经元钠钾通道电流的变化。

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4、

aim: to confirm and evaluate the efficacy and safety of oxiracetam in treatment of the organic brain syndrome.

目的：验证和评价奥拉西坦治疗器质性脑综合征的有效性和安全性。

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5、

clinical study of treating impediment of anamnesis and aptitude in the convalescent patients with severe head injury by oxiracetam

奥拉西坦治疗重型脑伤恢复期病人记忆与智能障碍的临床研究

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6、

oxiracetam in treatment of anamnesis and aptitude impediment in patients with mild to medium vascular dementia

奥拉西坦治疗轻中型血管型痴呆患者记忆与智能障碍

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7、

a randomized double-blind controlled multicenter study with oxiracetam for injection in treatment of organic brain syndrome

注射用奥拉西坦治疗器质性脑综合征随机双盲对照多中心研究

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8、

observation of therapeutic effect on cerebral infarct dementia treated with oxiracetam and cerebrovascular function therapy

奥拉西坦联合脑循环治疗仪治疗脑梗死后痴呆的疗效观察

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9、

effect of oxiracetam on acute mild head injuries

奥拉西坦对急性轻型脑伤患者功能的影响

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10、

evaluation with quantitative eeg on effect of oxiracetam on mild and moderate brain injury

定量脑电图对奥拉西坦治疗轻中型脑损伤疗效评价

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11、

clinical study of curative effect of oxiracetam injection on medium or serious brain injury

奥拉西坦注射液治疗中、重型急性脑损伤的临床研究

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12、

a clinical study on oxiracetam capsule for dementia therapy

奥拉西坦胶囊治疗痴呆临床试验研究

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13、

effect of oxiracetam on sodium and potassium channels in hypothalamic neurons of rat

奥拉西坦对大鼠下丘脑神经元钠钾通道电流的作用

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14、

the protein binding was found to be low.

结论：奥拉西坦是一吸收快、消除快、主要以原形药物由尿排泄、蛋白结合率低的药物。

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15、

clinical study of oxiracetam for mild or medium brain injury

奥拉西坦治疗轻中型脑伤的临床研究

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16、

clinical study of curative effect of oxiracetam injection on brain injury

奥拉西坦注射液治疗脑损伤的临床研究

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17、

methods a single dose of 2 or~ 4 g oxiracetam injection was given to 8 healthy volunteers in an open randomized crossover design. serum concentrations of oxiracetam were determined by hplc. data were processed by drug and statistics ( das) software.

方法采用开放随机交叉设计实验，用高效液相色谱法测定8名健康受试者分别单次静脉滴注2g或4g奥拉西坦后的血清中药物浓度，数据处理采用DAS软件处理。

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18、

objective to assess the clinical effect of treating impediment of anamnesis and aptitude by oxiracetam in the convalescent patients with severe head injury ( gcs3-8).

目的评价奥拉西坦（Oxiracetam）治疗重型脑伤（GCS3~8分）恢复期病人记忆与智能障碍的临床疗效。

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19、

treatment effects of oxiracetam on mild brain injury by p300 monitoring

P300监测对奥拉西坦治疗轻型脑伤的疗效观察

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20、

hplc determination of oxiracetam and related substances in oxiracetam sodium chloride injection

HPLC法测定奥拉西坦氯化钠注射液中奥拉西坦含量及其有关物质

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