Objective To investigate the relationship between the 4G/ 5G gene polymorphism of the plasminogen activator inhibitor 1 ( PAI 1) and myocardial and cerebrovascular infarctions.

Simple indel coding plays a different role on the phylogenetic results when percentage of gaps is different.

空位含量不同，简单插入缺失编码对系统发育分析结果的影响力也不同。

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A total sequence of 599 nucleotide base pair was obtained by alignment with homologous sequences of another two Sardinella species in GenBank. There were 445 parsimony-informative sites and 154 variation sites, but no insertion/ deletions were observed.

与GenBank中另外2种小沙丁鱼的同源序列比对，去除部分端部序列后得到599bp同源序列，其中包括445个简约信息位点，154个变异位点，没有发现碱基的插入缺失。

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Among these SNPs, there were no SNPs, insertions or deletions found in the OTC biosynthesis cluster. While in S. rimosus 23383, some SNPs were identified in the primary metabolites related genes.

在这些SNPs之中，与OTC合成基因簇相关的基因中不存在任何SNP和插入缺失，然而在23383菌株中，发现一些初级代谢基因中存在着SNP，这些变化可能最终影响了OTC的生物合成。

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These sequences contained 1,595 nucleotides, including 1,270 conserved sites, 21 single nucleotide polymorphisms ( SNPs), and 16 indels.

在获得的1595bp核苷酸序列中，有1270个保守位点，21个SNP位点和16个插入缺失（Indels）。

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Conclusion: The ACE gene insertion/ deletion polymorphism is associated with left ventricular hypertrophy in hypertension patients. It is not completed by increasing plasma AT-ⅱ level.

结论：ACE基因插入缺失多态性与高血压左室肥厚有关，但并非通过升高血浆AT-Ⅱ水平实现的。

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Sequence and Copy Number Variation of Oleate Desaturase Gene ( FAD2) in Brassica Species

芸薹属作物油酸脱饱和酶基因（FAD2）拷贝数和序列变异分析

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Known as copy number variants ( CNV), the genetic abnormalities are alterations within the chromosome which means a cell has an excess or an absence of a slice of DNA.

有些拷贝数变异是很常见的，但还有一些则在人类中极少发生或是发生的频率较低。

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A gene regulation network was then built to further identify genes responsible for differential gene expression and copy number variation between the chemotherapy resistant group and the chemotherapy sensitive group.

然后建一个基因调控网络进一步查明负责化疗耐药组和化疗敏感组之间的差异表达基因的拷贝数变异的基因。

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Small molecular-protien interaction and copy number variations ( CNVs) are always important analytes as they are closely concerned with human beings' work and livelihood.

小分子-蛋白质的相互作用、拷贝数变异与人类生产生活密切相关，因而一直是重要的分析研究对象。

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Notably, the mutation rates of 132 ( 3.0%) CNVs are at the order of 10-3 per generation, therefore, identified as hotspots.

值得一提的是，有132（3.0%）个拷贝数变异的突变率可达10-3/代水平，被认为是突变热点。

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Many scientific researches show that CNVs can result in different levels of gene expression and are connected with the normal phenotypic variation and human diseases.

许多研究结果表明，拷贝数变异可导致不同程度的基因表达差异，与正常表型的构成及疾病的发生发展具有一定的联系。

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In order to analyze possible epigenetic alterations caused by copy number variations, it is necessary to modify useful methods for breakpoint mapping.

为研究拷贝数变异可能带来表观遗传学改变，需要选择适当方法进行断点定位分析。

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Hence, constructing simple and rapid methods for the study of small molecules-protein interaction and copy number variations is significant in biological fields.

因此，建立小分子-蛋白质相互作用及拷贝数变异快速、简便的分析方法具有重要的生物学意义。

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Biological variation resulting from recombination, mutation, and selection. Copy-number variation: a new pattern of structural diversity in genome

生物多样性来自于基因的重组、变、筛选。拷贝数变异：基因组多样性的新形式

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Due to the high-resolution, high-throughput and high-accuracy, array-CGH is considered to be a powerful tool for submicroscopic CNVs detection.

微阵列比较基因组杂交具有高分辨率、高通量和高准确性等优点，适用于亚显微基因组拷贝数变异的检测。

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The combination of copy number variation and gene expression signatures help to understanding of potential mechanisms involved in drug resistance.

拷贝数变异和基因表达的整合分析有助于理解化疗耐药性的潜在机制。

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A large number of gene loci show variations in copy number, and many may be associated with disease susceptibility.

很多基因位点都有拷贝数变异现象，而且很多可能与疾病易感有关。

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We proposed a novel statistical method to approximately estimate the mutation rate of copy number variants ( CNVs).

其二，我们提出了近似估计拷贝数变异突变率的统计新方法。

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Copy number variations, mainly including deletions and amplifications, are main parts of chromosomal changes.

拷贝数变异，包括扩增、缺失等，是染色体结构改变的重要组成部分。

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Association between Copy Number Variants within Metabotropic Glutamate Receptors 7 Gene and Schizophrenia

代谢型谷氨酸受体7基因的拷贝数变异与精神分裂症的相关性

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