Accordingly, FGF21 is now considered a potential therapeutic agent to treat a variety of metabolic diseases including hyperglycemia and dyslipidemia ( 9).

Objective To improve the pediatrician's knowledge of the relationship between the symptom of coma, ketoacidosis and inborn error of metabolism through the summary of three cases of methylmalonic acidemia ( MMA) with initial symptom of coma.

目的通过对3例以昏迷为主诉而入院的甲基丙二酸血症（MMA）患儿的临床治疗及生化学监测的分析，提高儿科医生对昏迷、酸中毒与遗传代谢性疾病的关系的认识。

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PPARs stand on the cross-section of multiple transcriptional signaling pathways, and correlate well with varies of metabolism diseases and cancer.

PPARs处于多种信号转录途径的交叉点，与多种代谢性疾病和肿瘤密切相关。

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The overall incidence of NAFLD growed rapidly in the past fifteen years. The disease eventually develop cirrhosis or liver cancer, which makes the prognosis more serious.

NAFLD的整体发生率在过去的十五年迅速增长，多同时伴有代谢性疾病及心血管疾病，NAFLD最终可进展为肝硬化、肝癌。

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Doctor Anoop Misra is director of diabetes and metabolic disease at Fortis Hospital in New Delhi.

Anoop Misra医生是新德里富通医院糖尿病和代谢性疾病部门主任。

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Objective: The morbidity of diabetes mellitus ( DM) and impaired glucose tolerance ( IGT) is increasing with the effect of modern life style of high calorie and low activity.

目的：在高热量低活动量的现代生活方式影响下，代谢性疾病糖尿病（DM）和糖耐量减低（IGT）的发病率不断攀升。

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Pancreatic islet beta cell dysfunction is a very important and decisive element that SGA has adult-onset metabolic disease, though the mechanisms are not well understood.

胰岛β细胞功能障碍是SGA发生成人代谢性疾病的重要环节和决定性因素，然而具体机理尚不清楚。

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Small blood vessel is involved early, and many organs will be injured gradually. Diabetic retinopathy is one of the DM's main complications, is a main kind of disease which may cause blindness.

糖尿病是一个复杂的代谢性疾病，早期小血管受累，逐渐引起全身许多组织器官的广泛损害，糖尿病视网膜病变（Diabetic retinopathy，DR）是糖尿病的主要并发症之一，是一种主要的致盲眼病。

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Among various types of tumor associated transcription factors, Fox Family is the most important with large members. Developmental malformation, metabolic disease and tumorigenesis are related to its mutation and abnormality expression.

在与肿瘤相关的各类转录因子中，Fox家族蛋白成员众多，其突变和表达异常与发育畸形、代谢性疾病以及肿瘤发生密切相关。

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The SNPs of IL-6R gene associate with type 2 diabetes, obesity, hyperandrogenism and polycystic ovary syndrome.

IL-6R基因的外显子和内含子中均存在单核苷酸多态性（SNPs），IL-6R基因的SNPs与2型糖尿病、肥胖、雄激素过多症和多囊卵巢综合征等代谢性疾病具有相关性。

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Among the complex and diverse pathogenesis, pancreatic islet dysfunction is a very important element that links SGA with adult metabolic diseases.

SGA成年后患MS、T2DM的发病机制复杂多样，其中胰岛功能障碍是联系SGA与成人代谢性疾病的一个重要环节。

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Metabolic Disease Stroke Fabry Disease

代谢性疾病与卒中Fabry病

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Hepatocyte transplantation is an effective therapy on fulminant or acute hepatic failure and some liver-associated metabolic diseases.

肝细胞移植（HCT）是治疗暴发性或急性肝功能衰竭及某些和肝脏有关的代谢性疾病的一种有效的方法。

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Conclusion Near two-thirds of the dwellers over twenty years old in Wulian suffered chronic metabolic disease. IR was common in MS and chronic metabolic disease, especially in diabetes and MS.

结论五莲县20岁以上人群中近2/3者患有慢性代谢性疾病，IR在MS及慢性代谢性疾病中普遍存在，尤以糖尿病及MS为甚。

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Pathologic scar is a particular fibro-metabolic disease in human being. It results from wound, infection and burns etc.

病理性瘢痕（Pathologic Scar）是发生在人类皮肤创伤、感染和烧伤后一种纤维组织代谢性疾病。

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BACKGROUND Diabetes mellitus is a common chronic metabolic disease. It has becoming a severe public health problem.

背景糖尿病（DM）是一种常见的慢性代谢性疾病，现已经成为世界范围内日益严重的公共健康问题，严重危害着人类健康。

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Conclusion On CT, many diseases are manifested as symmetrical low density lesions at bilateral basal nuclei.

3讨论CT上表现为双侧基底核对称性低密度病变的疾病较多，主要包括代谢性疾病、感染性疾病和中毒性疾病。

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Fatty liver is a common metabolic disease for fish.

脂肪肝（Fatty liver disease）是一种鱼类常见的代谢性疾病，以肝细胞出现空泡变性、脂滴沉积为主要特征。

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Therefore, from safety considerations the CAA in the early and long-term applications were suitable for treatment with obesity and IR-related metabolic diseases.

因此从安全性考虑，CAA在早期和长期应用等方面都适用于治疗与肥胖和IR相关的代谢性疾病。

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Insulin resistance is the common pathophysiologic basis of multiple metabolic diseases, but the exact mechanism of insulin resistance is still unclear presently.

胰岛素抵抗（Insulin Resistance，IR）是多种代谢性疾病共同的病理生理基础，其确切发病机制目前尚无定论。

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With great changes in human lifestyle in recent years, the incidence of metabolic and endocrine diseases is rising yearly.

随着人类生活水平和生存环境的改变，代谢与内分泌疾病的发病率逐年上升。

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