With the increasing demand for antibody drugs, as well as more and more new products into clinical research, animal cell culture technology, as the core technology of modern bio-pharmaceutical industry, has achieved unprecedented development in the past decade.

1、

Driven by the huge market potential and the anxiety for breakthrough in current technical barriers, a new round of technical renovation is looming, and the result is expected to shuffle the entire field.

巨大的市场前景和亟待克服的技术问题及壁垒并存的现实不可避免地引发抗体药物的新一轮技术革命，而其结果又将毫无疑问地改变抗体药物的市场格局。

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The results of the research on mAbs have shown that their specificities mainly presents high special affinity, selective cytotoxicity to tumor cells in vitro, and targeting distribution in tumors and more effective therapy.

抗肿瘤抗体药物的研究表明，其特异性主要表现为特异性结合，选择性杀伤，体内靶向性分布以及具有更强的疗效。

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With the rapid development of biotechnology in the medical field and the knowledge of pathogenesis from the molecular level, monoclonal antibody drugs has become one of hot topics of cancer targeted therapy.

近年来，随着生物技术在医学领域的快速发展和从分子水平对发病机制的认识，单克隆抗体药物已成为恶性肿瘤靶向治疗领域的研究热点。

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In the following paper, the types, preparation, usage and limitation of monoclonal antibody therapeutics for tumor were summarized and the application prospect was forecasted.

文章就抗肿瘤单克隆抗体药物的种类、制备、应用及存在问题进行了综述，并对其应用前景进行了展望。

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The antitumor effects of monoclonal antibody therapeutics have been determined by a lot of researches for several years and provided crucial base for tumor therapy.

多年来，许多研究证实了抗肿瘤单克隆抗体药物的作用，为其应用于肿瘤治疗提供了重要依据。

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The team plans to develop an antibody drug to block the receptor from interacting with the T-cells and slow down the disease.

研究组计划研制出一种抗体药物以阻断与T细胞反应有关的受体来延缓疾病的发展。

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This article summarized development of the target therapy medicines for breast cancer from two aspects, antibody medicines and small molecular medicines.

现主要从抗体药物、小分子药物和芳香化酶抑制剂三个方面综述近年来在乳腺癌治疗药物的研究进展。

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But the low level of mammalian expression and laggard fermentation process constrained the development of antibody industry in China.

但是目前国内动物细胞表达水平普遍较低和发酵工艺落后的现状制约了我国抗体药物产业化的发展。

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On top of this, anti-TNF medications, used to decrease inflammation, also suppress the immune system.

除此之外，抗肿瘤坏死因子抗体药物，用来消炎，也抑制免疫系统。

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At the moment, antibody medicines and vaccines are produced in cell cultures inside stainless steel fermenters.

目前，抗体药物和疫苗产自于不锈钢发酵罐内的细胞培养。

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11、

Production of antibodies in plants

抗体药物的植物反应器生产

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The Development of a Novel Anti-VEGF Neutralizing Antibody and Mechanisms of Its Anti-renal Tumor Effects

新型血管生长因子抗体药物开发及抗肾肿瘤机制研究

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The Research of Monoclonal Antibody Drug Addiction

单克隆抗体药物进展

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Monoclonal Antibodies in the Treatment of Malignant Lymphoma

单克隆抗体药物在恶性淋巴瘤治疗中的应用

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The Age of Antibody-based Drugs is Coming& Current Status and Prospects

抗体药物时代的来临

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Evaluation on clinical application of 3 novel antineoplastic antibodies

3种新型抗肿瘤靶向抗体药物的临床应用状况评价

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Microbial biopharmaceuticals and antibody-based drugs& promising for new drug discovery and development

微生物药物和抗体药物&发现和研制新药的重要领域

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The Rocky Road of Therapeutic Antibody Development Over 20 Years

单克隆抗体药物风雨飘摇20年

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Adcetris is an antibody-drug conjugate that combines an antibody and drug, allowing the antibody to direct the drug to a target on lymphoma cells known as CD30.

Adcetris是一种抗体药物结合物，结合抗体和药物，允许抗体指引药物至淋巴瘤细胞上被称为D30靶点。

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At present, many antibody drugs targeting the EGFR have been market and showed good therapeutic effect in the clinical treatment of tumors in foreign countries, but there is still without the antibody of our own intellectual property rights listed on yet.

目前，国外已有多种以EGFR为靶点的抗体药物上市并在肿瘤临床治疗中表现出良好的治疗效果，但我国尚没有自主知识产权的抗体上市。

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