The Rocky Road of Therapeutic Antibody Development Over 20 Years

1、

Adcetris is an antibody-drug conjugate that combines an antibody and drug, allowing the antibody to direct the drug to a target on lymphoma cells known as CD30.

Adcetris是一种抗体药物结合物，结合抗体和药物，允许抗体指引药物至淋巴瘤细胞上被称为D30靶点。

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2、

At present, many antibody drugs targeting the EGFR have been market and showed good therapeutic effect in the clinical treatment of tumors in foreign countries, but there is still without the antibody of our own intellectual property rights listed on yet.

目前，国外已有多种以EGFR为靶点的抗体药物上市并在肿瘤临床治疗中表现出良好的治疗效果，但我国尚没有自主知识产权的抗体上市。

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3、

The treatment with antihistamines and anti-IgE antibodies have a therapeutic effect, but not the curative treatment for type I allergy. The administration of increasing doses of crude allergen extracts to patients may induce severe and life-threatening IgE-mediated anaphylactic side effects.

虽然相关抗组胺药物和抗IgE抗体药物临床上显示一定的疗效，但都不是对因治疗。传统过敏原粗提液使用时，会发生不良反应。

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4、

Intensified chemotherapy or autologous stem cell transplantation improves treatment outcomes only for some patients. The most striking and consistent improvement over CHOP chemotherapy in the treatment of DLBCL is the addition of anti-CD20 monoclonal antibody.

强化化疗方案或干细胞移植可改善某些患者的长期生存，最突出和一致改善弥漫性大B细胞淋巴瘤的长期生存效果则是随着抗CD20单克隆抗体药物与化疗的联合应用。

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5、

However, Herceptin recognizes p185~ HER-2 protein, it could not inhibit HER-2 gene expression directly.

但抗体药物作用于p185~（HER-2）蛋白，并不能从根本上抑制HER-2基因的表达。

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6、

The effect of anti human T lymphocyte monoclonal antibody on TNF and IL 2 level in aplastic anemia patients

抗T细胞单克隆抗体对再生障碍性贫血患者TNF和IL-2水平的影响

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7、

Studies on diagnosis of low-SiO_2 pneumoconiosis with monoclonal antibody against human dust cell

抗人尘细胞单克隆抗体用于低SiO2粉尘所致尘肺的诊断研究

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8、

Different epitopes in CD8 antigen defined with two monoclonal antibodies hit 8a and hit 8B

通过HIT（8a）和HIT（8b）两个单克隆抗体鉴定发现CD8抗原有不同的表位

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9、

The effects of AFP could be blocked by anti AFP monoclonal anti body.

AFP的作用均可被抗AFP单克隆抗体所拮抗。

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10、

Preparation of Monoclonal Antibodies Specific to Subtype H5N1 of Avian Influenza Virus

抗禽流感病毒H5N1亚型单克隆抗体制备初报

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11、

Effect of anti-Ia monoclonal antibody on allogeneic skin grafts in mice

抗Ia单克隆抗体对异基因小鼠皮肤移植物的影响

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12、

Four monoclonal antibodies are employed to mark colon cancer, adenocarcinoma of the colon, premalignant mucosa and normal colon mucosa by the histochemical S ─ P method.

应用4种单克隆抗体、通过免疫组化S－P法，对大肠癌、大肠腺癌、癌旁粘膜和正常大肠粘膜进行标志.72例大肠癌组织中阳性表达率分别为SC12A87.5%；

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13、

Preparation and identification of monoclonal antibodies against recombinant protein of TT virus

TT病毒重组蛋白单克隆抗体的制备

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14、

Methods Activation-dependent monoclonal antibodies and flow cytometry were used.

方法应用活化依赖的单克隆抗体和流式细胞术（FCM）。

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15、

LPS Analysis of Chinese Strains of Coxiella Burnetii by SDS-PAGE and Immunoblot with Monoclonal Antibodies

我国Q热立克次体脂多糖的SDS-PAGE和单克隆抗体免疫印迹分析

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16、

Therapeutic effect of agonistic CD40 monoclonal antibody combined with CTL on hu-SCID mouse B lymphoma model

激发型CD40单克隆抗体联合特异性细胞毒T淋巴细胞对B细胞淋巴瘤的免疫治疗作用

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17、

Effect of HI_ ( 47) ( CD_ ( 20)) monoclonal antibody on human B Iymphocyte activation and proliferation

HI（47）（CD（20））单克隆抗体对B细胞活化增殖的影响

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18、

Methods P53 monoclonal antibodies were studied by immunohistochemistry in 45 paraffin-embeded specimens of gliomata.

方法采用以p53单克隆抗体通过免疫组织化学ABC方法，对45例脑胶质瘤术后石蜡包埋切片标本进行分析。

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19、

Characteristic analysis of anti-human IgA monoclonal antibodies and their preliminary applications

抗人IgA单克隆抗体的特性分析和初步应用

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20、

The construction and clinical application of anti-HBsAg hybridoma cell line

抗HBsAg单克隆抗体杂交瘤的建立与临床应用

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