aromatase

Anastrozole is a new, highly selective nonsteroidal aromatase inhibitor indicated for the endocrine treatment of postmenopausal women with advanced breast cancer.

阿那曲唑是－种新型高选择性的非甾体类芳香酶抑制剂，临床用于绝经后妇女晚期乳腺癌的治疗。

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aromatase related brain development and neural regeneration

芳香化酶与脑的发育和再生的相关性

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Unlike tamoxifen, aromatase inhibitors do not cause menopausal symptoms, but they may increase risk of osteoporosis.

与三苯氧胺不同的是, 芳香抑制剂不会引起绝经期症状, 但可增加骨质疏松症危险.

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Present results suggested that the elevation of brain aromatase activities was associated closely with sex reversion, and the increasing 11-KT levels may be important for sex inversion induced by 17 α-MT in red-spotted grouper.

这些结果表明，脑部芳香化酶活性的显著升高与性逆转密切相关，17-αMT主要通过提高血清中11-KT水平诱导赤点石斑鱼发生性逆转。

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Conclutions: Effect of aromatase inhibitor in combination with cyclooxygenase-2 inhibitor on endometriotic explants of rat models proved obvious, and it was slightly superior to that of aromatase inhibitor alone.

结论：芳香化酶抑制剂联合环氧合酶-2抑制剂对大鼠内异症异位内膜的作用略优于单用芳香化酶抑制剂；

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The results suggest that P450 aromatase mainly involved in the development process of eggs, but its role is not clear in the testis development.

这些发现提示P450arom主要参与卵子的发生过程，在精巢发育中的作用尚不清楚。

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Synthesis of 4-substitute derivatives of 19-hydroxy-4-androstene-3,17-dione and their inhibiting activity on testosterone A-ring aromatase

19-羟基雄甾-4-烯-3,17-二酮4-取代物的合成及其对睾丸素A环芳香化酶的抑制活性

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Expression of Aromatase Cytochrome P450 Gene and Cyclooxygenase-2 mRNA in the Ectopic and Eutopic Endometrium of Women with Endometriosis

细胞色素芳香化酶基因及环氧合酶-2基因mRNA在子宫内膜异位症异位与在位内膜的表达

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diagnostic value of the detection of aromatase cytochrome p450 and ca_ ( 125) for endometriosis

芳香化酶细胞色素P450及CA（125）联合检测对子宫内膜异位症的诊断价值

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these include the introduction of aromatase inhibitors, new chemotherapy agents, and the novel antibody trastuzumab.

其中包括芳香酶抑制剂，新的化疗药物，以及实施新的抗体曲妥。

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To see if they could block this growth, the team started with the enzyme aromatase.

为了了解它们能否阻断这种生长, 小组开始用芳香酶作研究.

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Hormone therapy includes tamoxifen and aromatase inhibitors.

激素治疗包括三苯氧胺和芳香酶抑制剂.

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Effect of interleukin-1 β on aromatase activity in human osteoblast-like cells

白细胞介素1β对绝经后妇女成骨细胞芳香化酶活性的影响

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In males, androgen can be aromatized into estrogen by aromatase.

男性体内的雄激素可经芳香化酶作用转化为雌激素。

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While in the heterozygotic ZW embryo, expression of estrogen receptor, steroidogenic factor-1 and P450 aromatase might stimulate ovarian formation.

在异型配子ZW胚胎中，雌激素受体、类固醇生成因子-1和P450芳香化酶基因的表达可刺激卵巢的形成。

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It was also unclear why the aromatase inhibitors were causing these aches and pains.

也不清楚为什么芳香酶抑制剂会导致这些疼痛和痛苦.

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The application of aromatase inhibitors in ovulation induction

芳香化酶抑制剂在诱导排卵中的应用

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A Clinical Research of Prevention of Bone Loss by Liuwei Dihuang Pill on Breast Cancer Patients Treated with Aromatase Inhibitor

六味地黄丸预防乳腺癌患者服用芳香化酶抑制剂所致骨量丢失的临床研究

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The expression of sex steroids receptors and aromatase in the ovary and the scent gland of the Zaocys dhumnades were studied by immunocytochemical method.

还运用免疫细胞化学方法，对乌梢蛇卵巢及臭腺内的3种性类固醇激素受体和芳香化酶的表达情况进行了初步研究。

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Aromatase is a new target enzyme for designing anti breast cancer drugs.

芳香酶是研究抗乳腺癌药物的新靶酶.

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expressions of cyclooxygenase-2 mrna and aromatase cytochrome p450 mrna in endometrial polyps among women of reproductive age

环氧化酶-2及细胞色素芳香化酶基因mRNA在育龄妇女子宫内膜息肉中的表达

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Aromatase inhibitors, such as aminoglutethimide and anastrozole, work in a different way to lower estrogen levels.

氨 鲁米特 和阿那曲唑作为芳香酶抑制剂是通过另一途径来降低雌激素.

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Effect of Aromatase Inhibition on Gonadal Differentiation and Sexual Behavior of Chickens

抑制芳香化酶活性对母鸡性腺分化和性行为的影响

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Exemestane is a third-generation steroidal aromatase inhibitor which can cause inactivation of aromatase enzyme by binding irreversibly to the substrate binding site and can be used to treat advanced breast cancer in postmenopausal women.

依西美坦为第三代甾体类芳香化酶抑制剂，临床上治疗绝经后妇女晚期乳腺癌，作用机制为与芳香化酶底物结合位点不可逆结合使芳香化酶失活。

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OBJECTIVE : To summarize the aspect of clinical evaluation and progression aromatase inhibitors the treatment of cancer.

目的: 介绍芳香化酶抑制剂的研究进展,评价其在乳腺癌治疗中的应用及临床价值.

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Objective To evaluate the diagnostic value of examining endometrial biopsy specimens for aromatase cytochrome P450 and CA_ ( 125) for endometriosis.

目的：探讨子宫内膜芳香化酶细胞色素P450（简称芳香化酶P450），CA125联合检测对子宫内膜异位症（简称内异症）的诊断价值。

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as cytochrome p450 aromatase can catalyze the conversion of androgens to estrogens, it is considered as a key enzyme in the hormonal steroidogenic pathway.

细胞色素P450芳香化酶能够催化雄性激素向雌性激素的转化，被认为是类固醇激素代谢过程中的一个关键酶。

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Objective to improve the synthetic procedure of aromatase inhibitor-anastrozole.

目的改进芳香化酶抑制剂阿那曲唑的合成工艺。

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Aromatase, a cytochrome P450 ( CYP19) enzyme, catalyzes the rate-limiting aromatization step for the conversion of androgens to estrogens and is an effective target for inhibition of estrogen biosynthesis to treat hormone-sensitive breast cancer in postmenopausal women.

芳香化酶（CYP19）是生物体催化雄性激素转变为雌性激素的限速酶，其抑制剂在绝经后雌激素受体阳性乳腺癌患者的治疗中具有重要地位。

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