agrin

Objective To investigate whether agrin, a key protein in formation of neurological synapse, is expressed in lymphocytes and activate lymphocyte through affecting the formation of immunological synapse.

目的研究在神经突触形成中发挥重要作用的集聚蛋白（agrin）是否在淋巴细胞中表达并影响淋巴细胞的活化和免疫突触的形成。

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In activated lymphocytes agrin was co-capping with CD3 molecules and this capping-like structure formation was interfered by antibody against agrin.

经共聚焦显微镜观察发现，集聚蛋白在活化的淋巴细胞中以帽化结构形式存在，且和CD3分子共定位，抗集聚蛋白抗体可以明显减少这种帽化结构的形成。

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Agrin activates PAK 1 , and the activation of PAK 1 by agrinrequires Dvl.

抑制PAK1激酶的活性会抑制Agrin引起的乙酰胆碱受体聚集.

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Methods RT-PCR was performed to detect the expression of agrin in resting and activated lymphocyte; real time PCR was conducted to analyze the correlation between agrin expression and lymphocyte activation status;

方法应用RT-PCR检测集聚蛋白在静止和活化淋巴细胞中的表达，并应用实时定量PCR检测分析集聚蛋白的表达量与淋巴细胞活化之间的关系；

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MuSK, Dvl and PAK 1 form complex among them.

Agrin会 增加肌肉细胞中PAK1的激酶活性.

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Influence of concentration of potassium in culture medium on expression of agrin from cortical neurons in vitro

体外培养大鼠皮质神经元兴奋性对Agrin表达的影响

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The expression of agrin in rat cortex during the postnatal time

蛋白聚糖在发育期大鼠大脑皮质的表达

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The immunohistochemical staining showed an increasing deposition of the agrin protein near the endplate at 1 and 5 weeks after the operation, but decreasing remarkably to the level of control groups at 10 weeks postoperatively.

免疫组化显示agrin基因转染后，术后1周到5周，有大量棕黄色抗原抗体复合物沉积在终板及其邻近区域，但到第10周时表达明显减少，接近对照组水平。

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