vpa

Comparing to the ordinary tablet, Cmax in VPA sustained-release tablets decrease, Tmax increases, and MRT prolongs.

与普通片相比,VPA缓释片的Cmax减少, Tmax增大, MRT明显延长,显示明显的缓释特征.

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CONCLUSION A PPK model of VPA in children with epilepsy in China is successfully established using the NONMEM software.

结论用NONMEM软件成功地建立了中国癫痫儿童VPA的PPK模型。

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VPA, TPM and CNZ were the most effective medicines, LTG and CBZ aggravated in most of patients.

药物治疗以丙戊酸、托吡酯、氯硝安定的疗效最好，拉莫三嗪和卡马西平使大部分患者加重。

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Describes how to direct the runtime to use the DEVPATH environment variable when searching for assemblies.

描述如何指示运行时在搜索程序集时使用DEVPATH环境变量.

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VPA in combination with chemotherapeutics 5-FU, DDP or ADM had synergistic antitumor effects.

丙戊酸钠分别与化疗药5-FU、DDP、ADM联合有体外协同抗肿瘤作用。

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If you see the following welcome view, VPA ran successfully.

如果看到下面的欢迎视图，就说明VPA已经成功地运行了。

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CBZ had significant higher retention rate than VPA-Mg and Combined therapy in the first year.

治疗的第一年，卡马西平的保留率明显高于丙戊酸镁与联合治疗。

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The Inhibitory Effects of VPA on Angiogenesis of Human Ovarian Cancer in Nude Mice

丙戊酸对卵巢癌裸鼠移植瘤血管形成的影响

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The rats in the experimental groups were administered with TPM 40 mg/ kg, TPM 80 mg/ kg and TPM 40 mg/ kg+ VPA 300 mg/ kg respectively by gavage on day 6 through 15 of gestation.

实验组3组，于妊娠6～15d分别经口灌胃给予TPM40mg/kg，TPM80mg/kg和TPM40mg/kg+VPA300mg/kg。

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Monitoring VPA levels in serum of epileptic patients is desirable mainly for study its pharmacokinetics and drug-drug interaction.

人体内丙戊酸血浓度测定方法的建立对于研究其药物动力学及药物相互作用研究具有重要意义。

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A positive relationship between the free PHT fraction and VPA concentration was found.

同时VPA浓度与PHT游离部分有明显相关性。

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Some of the patients had different degrees of mental developing retardation, some had abnormality on brain imaging. On medicine treatment, VPA, TPM and CNZ were the most effective medicines. LTG and CBZ could be beneficial or aggravated.

部分患者有不同程度精神智力发育迟滞，部分有影像学异常，药物治疗以丙戊酸、托吡酯、氯硝安定的疗效最好，拉莫三嗪和卡马西平疗效多样，或有效或加重。

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Valproic Acid ( VPA), a histone deacetylase inhibitor, could specifically inhibit the histone deacetylase activity, increase histone acetylation, and active gene expression in somatic cells.

丙戊酸（valproic acid，VPA）作为一种组蛋白去乙酰化酶抑制剂，能特异性抑制组蛋白去乙酰化酶的活性，提高细胞内组蛋白乙酰化水平，激活基因的表达。

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Empirical Study on the Mechanism of the Apoptosis Induced by VPA

丙戊酸诱导白血病U937细胞凋亡机理的实验研究

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NPY 、 Caspase-3 Expression in Hippocampus and in Cortex of Rat Model of Temporal Epilepsy During Different Periods and Effected by VPA and NGF

颞叶癫痫鼠脑海马、皮层不同时期NPY、Caspase-3的表达及VPA和NGF对它们的影响

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