tumorigenesis

Among various types of tumor associated transcription factors, Fox Family is the most important with large members. Developmental malformation, metabolic disease and tumorigenesis are related to its mutation and abnormality expression.

在与肿瘤相关的各类转录因子中，Fox家族蛋白成员众多，其突变和表达异常与发育畸形、代谢性疾病以及肿瘤发生密切相关。

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Conclusion Mutational inactivations of APC gene were detected in more than half of HNPCC patients in this study, indicating that APC mutation is a common molecular event in the tumorigenesis of HNPCC.

结论多于半数的HNPCC发生APC突变，其突变多发生在编码区单核苷酸重复序列（移码突变）或CpG岛（点突变）上，提示APC基因失活在HNPCC为常见的分子事件；

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Activation of oncogene and loss of functions of tumor suppressor genes resulting from instability of human genome is one of the mechanisms in tumorigenesis.

基因组的不稳定导致的癌基因激活、抑癌基因丢失或失活是肿瘤发生的机制之一。

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This article reviews the structure, function and the relationship to the tumorigenesis of the IKK.

本文综述了IKK的结构、功能，及其与肿瘤发病的关系。

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DNA methylation and its aberrance play an important role in the human development and tumorigenesis.

DNA的甲基化及甲基化异常在人体发育和肿瘤的发生中起着至关重要的作用.

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So , it is possible that NAG 73 and the product act on the tumorigenesis of nasopharyngeal carcinoma.

NAG73可能可编码产物.该产物在鼻咽癌的发病发展中发挥作用.

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Accordingly, it is believed that netrin-1 and its receptors may play an important role in tumorigenesis.

因此, netrin1 及其受体可能在肿瘤发生过程中发挥重要作用.

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The Functions of Telomerase in Cell Immortalization and Tumorigenesis

端粒酶在细胞永生化和癌变中的作用

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All these findings demonstrated the role of REG in tumorigenesis.

这些都说明了REGγ在肿瘤发生发展中的作用。

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Objective To determine whether the K12 gene of Kaposi ′ s sarcoma-associated herpesvirus ( KSHV) can transform the mouse fibrosis cell lines NIH3T3 in vitro and to induce tumorigenesis in vivo.

目的证实卡波济肉瘤相关疱疹病毒（KSHV）K12基因在体外可以转化小鼠成纤维细胞系NIH3T3细胞，体内可以诱导肿瘤的形成。

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Cell Cycle Checkpoint Control and Tumorigenesis

细胞周期关卡调控与细胞癌变

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research progress of mechanisms of cell transformation and tumorigenesis induced by polyomavirus

多瘤病毒诱导细胞转化和致瘤机制的研究进展

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The Effect of Dietary Oil and Exogenous Cholate on Colon Tumorigenesis, Blood Glucose and Blood Lipids in Mice

胆盐和食用油脂对小鼠结肠肿瘤形成及血糖血脂的影响

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Changes of telomerase activity in the tumorigenesis of rat submandibular gland

大鼠颌下腺肿瘤形成过程中端粒酶活性的变化

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By virtue of soft-agar colony forming assay and nude mouse tumorigenesis test, the transforming ability in vitro and the tumorigenesis ability in vivo of K12 gene were respectively identified.

采用软琼脂集落形成试验和裸鼠成瘤试验，分别证实K12基因体外转化细胞和体内致瘤特性。

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The role of the homeobox gene in gastrointestinal development and gastrointestinal tumorigenesis

同源盒基因在胃肠道发育与胃肠道肿瘤发生中的作用

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Results The NIH3T3 cells transformed with K12 gene formed colony in soft agar and induce tumorigenesis in nude mouse.

结果K12基因转化的NIH3T3细胞在软琼脂中可以形成集落、在裸鼠体内可以形成肿瘤；

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Objective To study h Spry 2 gene's role in the tumorigenesis.

目的探讨h Spry2基因在136例肿瘤发生中的作用。

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Gastric tumorigenesis is a complicated process involved a lot of steps and aberrant genes.

胃癌的发生发展是一个涉及多基因多步骤的复杂过程.

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The interaction of multiple genes plays an important role in tumorigenesis.

这些基因间的相互关系对肿瘤发生有重要意义.

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After cultured in vitro, the tumorigenesis ratio increased to 100%, the latency period ranged from 7 to 10 day, metastasis and spontaneous regression were not observed.

经体外传代后移植瘤成活率100%，潜伏期7～10d，无自然消退，无转移。

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Angiogenin ( ANG ) can strongly stimulate blood vessel formation and play an important role in tumorigenesis.

血管生成素 ( angiogenin,ANG ) 是一个强有力的促血管生成因子,与肿瘤的发生、发展密切相关.

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But the mechanism of the tumorigenesis of SV 40 Tag is not clear.

目前对SV40在肿瘤发生过程中所扮演的具体角色和确切机制还不十分清楚.

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The structure, function of α actinin and its role in tumorigenesis were reviewed.

本文结合本实验室的研究工作，综述了α辅肌动蛋白家族成员的结构、功能及其与肿瘤发生的相关性。

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One is as a structural component of adherens junction, which forms the cadherin-catenin complex to mediate intercellular adhesion. The other is as a downstream effector of Wnt signaling pathway, which controls essential steps in many aspects of embryogenesis and tumorigenesis.

一是作为附着连接的组成部分，与钙粘蛋白结合形成复合体参与细胞间连接；二是作为信号分子，是Wnt信号途径的重要环节，在胚胎发育和肿瘤发生中起重要作用。

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DNA Methylation: An Epigenetic Mechanism for Tumorigenesis

DNA甲基化&肿瘤产生的一种表观遗传学机制

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If not repaired, the breakage can result in lethality or chromosome breakage, and if misrepaired, it can cause mutation, gene instability and the increased rate of tumorigenesis.

双链断裂得不到修复，细胞将会死亡或发生染色体断裂、丢失，若是错误修复将导致基因突变或基因组不稳定，增加癌症的风险度。

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This paper focus on the role of the homeobox gene in gastrointestinal development and tumorigenesis.

此文对同源盒基因在胃肠道发育及胃肠道肿瘤发生中的作用作一综述。

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Our work established the connection between TAZ and Hippo pathway. It is very meaningful to fully understand the physiological function of the pathway, and the role of TAZ/ TEAD playing in tumorigenesis and human cancer development.

我们的发现建立了TAZ与Hippo Pathway的联系，对于阐明Hippo Pathway在哺乳动物细胞中的生理功能和TAZ、TEAD在肿瘤发生和癌症发展中的作用具有重要意义。

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Tumorigenesis is cogently associated with the activation of telomerase.

端粒酶与肿瘤的发生有十分密切的联系。

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