tryptase

AIM: To explore the effects of zanthoxylum seed oil ( ZSO) on mast cells in lung tissue and tryptase in plasma of asthmatic models in guinea pigs and to provide theoretical basis for the treatment of asthma by using ZSO.

目的：探讨椒目油（ZSO）对豚鼠哮喘模型肺组织中肥大细胞及血浆类胰蛋白酶的影响，为ZSO治疗哮喘提供理论依据。

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The stainability of the tryptase positive mast cells in these species could be partly inhibited by some trypsin inhibitors such as Lina been trypsin inhibitor ( LBTI),α 1 antitrypsin and Aprotinin.

类胰蛋白酶阳性肥大细胞的酶组织化学染色可被利马豆胰蛋白酶抑制物（LBTI）、α－1－抗胰蛋白酶及Aprotinin等胰蛋白酶抑制物部分抑制。

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The Change of Tryptase 、 Complement C3 、 C4 、 NF-κ B and Intervention Study of Dexamethasone in Amniotic Fluid Embolism after Laboring in Rats

大鼠羊水栓塞后类胰蛋白酶、补体C3、C4、核因子-κB的变化及地塞米松干预的研究

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AIM: To investigate the effect of tryptase inhibitors ( TPIs) on histamine release from human colon mast cells.

目的：研究类胰蛋白酶抑制剂（TPI）对人大肠肥大细胞释放组胺的影响。

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Methods: Using doubling immuno-colloidal gold labeling of anti-tryptase ( AA5) and anti-chymase ( CC4), the ultrastructure of secretory granule in mast cell was observed by transmission electron microscope.

方法：用双重免疫胶体金标记类胰蛋白酶抗体（AA5）及类糜蛋白酶抗体（CC4），在透射电子显微镜下观察肥大细胞内分泌颗粒的超微结构。

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Result: There was little characteristic morphological changes during autopsy, but the specific IgE against bee venom could be detected, besides, RAST index and the serum tryptase level was high during serolog examination.

结果：蜂类螫刺致死尸体往往缺乏特征性形态学改变，但有蜂毒特异性抗体IgE血清学检查RAST指数和类胰蛋白酶水平的升高。

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Results The activity of tryptase of sera, lungs and bronchial tubes increased significantly in Anaphylactic guinea-pigs compared with control group.

结果过敏性休克豚鼠血清，肺，气管类胰蛋白酶活力均增加，且三者增加的程度是平行的。

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Histamine and tryptase release were not altered by ketotifen.

组胺和类胰蛋白酶的释放在使用酮替芬后没有变化.

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Result Renal fibroblasts were successfully cultured. Mast cell tryptase ( 10~ 500ng/ ml) promoted expression of PAR-2 mRNA and MCP-1 mRNA of human renal fibroblasts in heparin-dependent manner.

结果成功培养了人肾成纤维细胞，肥大细胞类胰蛋白酶（10～500ng/ml）可促进肾间质成纤维细胞PAR2和MCP1mRNA的表达，且依赖于肝素的存在。

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