norfloxacin

This article deals with the study on preparation of the microcapsules of norfloxacin with ethyl cellulose walled by the solvent nonsolvent method.

研制溶剂-非溶剂法制备诺氟沙星微囊以乙基纤维素为囊材的最适溶剂-非溶剂系统的组成。

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Objective The bioavailability and pharmacokinetics of norfloxacin capsula and suppository in 8 healthy volunteers were studied.

目的：研究氟哌酸胶囊和栓剂在人体中的药代动力学参数和生物利用度。

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It is reported that norfloxacin with europium ion can form energy transfer complex.

首次报道了氟哌酸可以和铕离子形成能量转移络合物而发射铕离子特征荧光.

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Results Of the 28 gonococcal isolates, resistant rates to penicillin, tetracycline, ceftri-axone, spectinomycin, norfloxacin were 28. 57%, 57. 14%, 14. 29%, 0% and 75. 00%, respectively.

结果：28株淋病双球菌的耐药率青霉素G为28.57%、四环素为57.14%、头孢三嗪为14.29%、壮观霉素为0%、氟哌酸为75.00%。

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OBJECTIVE To a method for the determination of metronidazole and norfloxacin in Pikangling.

目的测定皮康灵中甲硝唑和诺氟沙星的含量.

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Norfloxacin capsules was the highest in DDDs and the lowest in DDDc;

DDDs最高DDDc最低的是诺氟沙星胶囊；

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OBJECTIVE : To conduct stability study on norfloxacin eye drops at 25℃ and for predicting its expiry term.

研究诺氟沙星滴眼液稳定性,并预测其室温贮存有效期.

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Staphylococcus aureus and Escherichia coli resistant to nalidixic acid and norfloxacin were above 50%, while Salmonella paratyphi A was 96 97%, whose drug resistance to ampicillin and cefazolin had an obvious rise also ( P0.01);

金黄色葡萄球菌和大肠埃希菌对萘啶酸和诺氟沙星的耐药升至50%以上，甲型副伤寒沙门菌则高达96%～97%，对氨苄西林、头孢唑林也都有明显升高（P0.01）；

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Fluorescence Enhancement of Europium-Norfloxacin System by Lutecium

镥对铕-诺氟沙星体系的荧光增强效应

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For mice infected by Escherichia coli. the ED50, value of ofloxacin injection was 0. 26mg/ kg and the ED50 Value of Norfloxacin injection was 0. 75mg/ kg.

经实验，国产氧氟沙星注射液对大肠杆菌感染小鼠的ED（50）为0.26mg/kg，诺氟沙星注射液的ED（50）。

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The sensitivity of Sulperazone, Amikacin, Ciprofloxacin, Norfloxacin were 100%, 92.31%, 94.74%, 81.82%, The sensitivity of Rocephin, Cefotaxime, Maxipime were about 70%. The sensitivity of Chloromycin, SMZ-TMP and Ampicillin were under 18%.

舒普深、阿米卡星、环丙沙星、诺氟沙星敏感性分别为100%、92.31%、94.74%、81.82%，罗氏芬、头孢噻肟、马斯平的敏感性在70%左右，氯霉素、复方新诺明、氨苄青霉素的敏感性在18%以下。

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Methods 316 cases with bacillary dysentery of positive stool culture were divided into 6 groups at random, and they were treated with Norfloxacin ( NFX), NFX+ Berberine, Ofloxacin ( OFX), OFX+ Berberine, Ciprofloxacin ( CPFX), CPFX+ Berberine respectively.

方法将316例粪便培养阳性的细菌性痢疾患者随机分为6组，应用氟哌酸（NFX）、氟嗪酸（OFX）、环丙氟哌酸（CPFX）单用及分别联合黄连素进行治疗；

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Aim A method was set up to determine the content of Norfloxacin, by which the interference of other compositions could be avoided without the need to separate the interferential compositions from the Norfloxacin Eyedrop.

目的建立一种不经分离，可消除诺氟沙星滴眼液中其它成份干扰的含量测定方法。

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The results showed that the minimal lethal dose of Norfloxacin to embryos is 320mg/ kg embryo weight, and the lethal dose 50% ( LD60) for 3-day-old chicks 4 985+ 753.18 tag/ kg body weight.

结果表明，氟哌酸对鸡胚的最小致死剂量为320mg/kg胚重；对3日龄雏鸡的LD（50）为4985±753.18mg/kg体重。

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METHODS: Norfloxacin was determined by UV spectrophotometry, prediction of expiry by initial average rate methods.

方法: 采用紫外分光光度法测定诺氟沙星滴眼剂含量, 采用初匀速法预测其有效期.

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Results: The epileptiform discharges appeared in norfloxacin combined with BPAA group, accompanied with limb twitching and clonic tonic seizures.

结果：诺氟沙星BPAA组大鼠EEG示痫样放电，并伴有局部抽搐和全身强直痉挛发作等行为学改变；

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The author has verified the direct influence of Zn+ content in a new material upon norfloxacin reaction rate through a series of tests.

作者通过一系列实验证实了原料中锌离子含量的高低直接影响缩环收率。

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Probing into the Influence of Norfloxacin Reaction Rate of Metallic Ions

探讨金属离子Norfloxacin缩环反应收率的影响

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Elimination of conjugative drug resistance ( R) plasmids and non conjugative drug resistance ( r) plasmids from 20 and 19 Shigella strains respectively by norfloxacin and berberine in vitro were analysed.

用氟哌酸和黄连素对20株携有接合传递耐药性质粒（R质粒）及19株携有非接合传递耐药性质粒（r质粒）志贺氏菌进行体外消除研究。

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The micronization of norfloxacin ( average particle size was 1.37 μ m) improved the dissolution rate.

诺氟沙星经微粉化后，平均粒径为1.37μm。

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Preparation and application of compound norfloxacin nasal drops

复方诺氟沙星滴鼻液的制备与应用

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The rates of sensitivity to aminopenicillin ( AMP ) , chloramphenicol ( CMP ) , kanamycin ( KM ) , complex sulfamethoxazole-trimethoprim ( COS ) , gentamicin ( GN ) , neomycin ( NM ), tobramycin ( TOB ) , amikacin ( AKN ) and norfloxacin ( NOR ) were high, between 84.4 % and 95.5 %.

对链霉素、痢特灵 、 羧 苄青霉素及 四环素 的耐药率较高, 在129%～457%之间, 对红霉素的耐药率高达949%.

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Fluorescence Characteristics of Iron(ⅲ)-Norfloxacin-Guanylic Acid Ternary Complex

铁（Ⅲ）-氟哌酸-鸟苷酸三元络合物的荧光特性

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