1、

It has been believed that the homeostasis of telomere is regulated by telosome which consists of telomere, telomerase and telomeric proteins.

最近发现端粒长度的动态平衡是由端粒、端粒酶、端粒结合蛋白组成的高分子复合体&端粒体调节的。

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Therefore, normal human cells lack telomerase activity, their telomeric DNA lengths decrease gradually with the increasing numbers of cell divisions, eventually telomeres shortening induce cellular replicative senescence.

因此正常人体细胞缺乏端粒酶活性,端粒DNA长度随细胞分裂次数增多逐渐缩短,最终引起细胞复制衰老。

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Telomeric DNA formats G-quadruplex, thereby inhibits telomerase activity. Also, formation of G-quadruplex in promoters of several oncogenes can inhibit expression of oncogenes.

端粒末端DNA形成G-四螺旋,能阻止端粒酶发挥功能,抑制端粒酶活性,另外在一些癌基因的启动子区域也可形成G-四螺旋,控制癌基因。

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We report the identification of a splice donor mutation in a novel gene, which is the mouse ortholog of a newly discovered telomeric regulator.

我们报告了一个新基因左拼接剪接变异的证据,这个新基因是一个新发现的鼠同源基因端粒调节体。

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Objective: Telomerase is a ribonucleoprotein complex that synthesizes telomeric DNA onto chromosome ends using its RNA component as template, enabling extension of cell lifespan and even immortalization.

目的:端粒酶是一种核糖核蛋白复合物,能以自身RNA成分为模板催化染色体末端端粒重复序列的延伸,使细胞得以持续增殖甚至永生化。

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The reverse transcriptase telomerase is able to maintain stable telomeric length and essential for the unlimited proliferation of tumor cells. Telomerase activity has been detected in 85-90% of human tumors and tumor-derived cell lines but not in most human somatic cells.

端粒酶表达于85%以上的肿瘤细胞中,能够维持细胞中端粒的长度,对永生化细胞的增殖具有重要作用,而在大多数人正常体细胞中却没有表达。

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9、

Comparison and observation on chromosome telomeric associations in human lung cancer

人肺癌染色体端粒联合的比较观察

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Advances in the regulation mechanism of the telomeric length

端粒长度调控机制的研究进展

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Specific Attachment of Telomeric DNA to Nuclear Matrix in Hela Cells

HeLa细胞染色体端粒DNA与核骨架的特异性结合

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Primary Study on Spectrophotometric Detection of Telomeric DNA with Catalytic Beacons

催化信标检测端粒DNA序列的初步研究

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Expression of fibronectin gene in pancreas carcinoma Human Telomeric Protein

人粘连蛋白基因在胰腺癌中的表达

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The role of telomeric length alteration in salivary tumor transformation

端粒长度变化在涎腺肿瘤发生中的作用

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Preparation and characterization of monoclonal antibody against human telomeric repeat binding factor 1

抗人端粒重复序列结合因子(TRF1~(33-277))单克隆抗体的制备及生物学特性初步鉴定

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16、

The molecular interaction between P53 and telomeric repeat binding protein 1 in vitro

P53与端粒重复序列结合蛋白质1的体外相互作用

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Minute Chromosome Rearrangement Detected by Human Telomeric Band Painting Probes

应用端粒区带涂染探针检测染色体微小结构重排

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In vitro binding of p53 and telomeric repeat factor 2

端粒重复因子2与p53的体外结合

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Detection of telomerase activity in human lung cancer by silver staining telomeric repeat amplification protocol

银染端粒重复序列扩增法检测肺癌端粒酶活性

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Telomeric loss in head and neck squamous cell carcinomas

染色体端粒的缺失表达在头颈部磷癌的意义

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