1、

Objective To investigate the effects of Arg-Gly-Asp-Ser ( RGDS) tetrapeptide on integrin signaling and apoptosis in fibronectin ( FN)-stimulated hepatic stellate cells ( HSCs).

目的探讨精-甘-天冬-丝氨酸(RGDS)四肽对经纤维连接蛋白刺激的肝星状细胞(HSC)凋亡的影响及整合素信号通路在其中的作用。

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2、

Methods Using in situ RT_PCR technique, the spatial and temporal expression pattern of both fibronectin and integrin β 1 mRNA was detected on paraffined slices in different rabbit mandibular fracture healing phases.

方法取兔下颌骨骨折愈合各时期标本的石蜡切片,采用原位逆转录多聚酶链式反应技术,检测骨折愈合过程的不同时期FN和Itgβ1mRNA的时空表达。

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Objective To identify the mutation of integrin αⅱ b β 3 in four probands with Glanzmann thrombasthenia through phenotype and gene diagnosis and investigate molecular pathogenesis of GT.

目的:对4例遗传性血小板无力症(GT)先证者及其父母进行表型和基因诊断,确定基因突变的位点,并探讨其分子发病机制。

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4、

Conclusion: RGD peptide as an Alpha ( v) integrin antagonist has not only targeted drug delivering function but also direct tumor-killing effects. RGD peptide is an ideal therapeutic agent for potential tumor targeting therapy.

结论:RGD肽作为αv整联蛋白的一种拮抗剂,不仅具有药物、基因治疗载体的导向运输功能,更具有肿瘤的直接杀伤效应,是一种理想的肿瘤靶向性治疗药物。

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Biological significance of expression of integrin α_5 β_1 and α_v β_3 in squamous carcinoma of tongue

人舌鳞状细胞癌中整合素α5β1、αvβ3表达的生物学意义

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Methods Immunohistochemistry was used to detect the difference of β 1 integrin expression in B-lymphoma, T-lymphoma, and reactive hyperplasia lymph nodes.

方法免疫组化法检测B细胞淋巴瘤、T细胞淋巴瘤和反应性增生淋巴结中β1整合素表达的差异;

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it connects with the integrin and assembles other molecules to the conjunction site forming signal complex. the signal complexes then transduce the extracellular signal to the cytoskeleton. this mediates the cell adhesion and migration.

它与整合素受体相连接并聚集其它分子于连接位点,形成信号复合体,将细胞外信号向细胞骨架传递,调节细胞的粘附、迁移。

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8、

Effects of trehalose on human skin β 1 integrin expression and activity

新型抗冻剂海藻糖对皮肤组织β1整合素及活力影响的研究

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The relationship between integrin β_3 subunit and estrogen receptor, progesterone receptor on endometrial epithelial cells of luteal phase defect

黄体功能不全患者子宫内膜上皮细胞整合素β3亚单位与孕激素受体关系

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Study of Signal Transduction Mediated by Integrin α IIb β 3 Using a Dominant Negative Model

利用显性阴性模型对整合素αIIbβ3介导的信号转导的初步研究

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Elimination of the Integrin α 6 β 1 Laminin Receptor on Human Hepatocellular Carcinoma Cell Surface by a Dominant Negative Strategy

以dominant negatiVe策略消除人肝癌细胞表面层粘连蛋白受体α6β1的功能

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Effects of Ovulation Induction Therapies on Endometrial Integrin α_v 、β_3 Expression in Patients with Polycystic Ovarian Syndrome Related Infertility

促排卵治疗对多囊卵巢综合征患者子宫内膜整合素αv、β3表达的影响

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Expression of c-fos and integrin-β_3 in eutopic endometrium during implantation window in endometriosis

C-fos和整合素β3在子宫内膜异位症窗口期在位子宫内膜的表达

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The expression of integrin was consistent with that of ILK.

Integrin的表达与ILK平行。

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Expression and Significance of Integrin Linked Kinase ( ILK) in Pancreatic Adenocarcinoma

整合素连接激酶(ILK)在胰腺癌中的表达及意义

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Here we investigated whether integrin-linked kinase ( ILK) may regulate LV remodeling and function after myocardial infarction.

本研究调查了整合素相关肌酶(ILK)是否可以调节心肌梗死后左室重塑及功能。

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Expression and significance of integrin α_5 β_1 and E-CD in patients with non-small cell lung carcinoma

非小细胞肺癌组织中整合素α5β1和上皮钙黏连素的表达

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Significance of DNA ploid analysis and expression of e-cd, integrin α 5 β 1 and MMP-2 in lung carcinoma

DNA倍体分析和E-CD、Integrinα5β1、MMP-2的表达在肺癌中的意义

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Role of Integrin and Focal Adhesion Kinase in the Regulation of Human Pulmonary Artery Smooth Muscle Cells Migration Induced by Inhibition of JWA Gene in vitro

整合素和粘着斑激酶在JWA基因抑制诱导的人肺动脉平滑肌细胞迁移调控中的作用

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( 2) The different expression of Integrin β 3 among three groupsIntegrin β 3 was situated in endometrium glandular epithelium and ( or) cavitas epithelial cells. There was only a little expression in stroma-cell.

三组患者窗口期子宫内膜组织中整合素β3的表达差异整合素β3定位于子宫内膜腺上皮细胞和(或)腔上皮细胞,基质细胞仅极少量表达。

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