the general development mechanism of traditional chinese medicine in anti-kidney fibrosis

1、

recent studies demonstrated that mirna could regulate emt in different kind of cells and it was shown effective to inhibit organ fibrosis, such as cardiac, liver, lung, renal fibrosis as well as systemic sclerosis, by targeting mirnas to reverse emt.

最新的研究表明，miRNAs参与调节多种组织细胞EMT过程，靶向miRNA可以有效逆转EMT并抑制器官纤维化，包括心脏、肝脏、肺、肾纤维化，系统性硬化等。

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2、

it has been proven that of erk was involved in the transforming growth factor-β 1 ( tgf-β 1) or aldosterone-induced emt of the proximal tubular epithelial cells and renal fibrosis.

ERK参与转化生长因子β-1（TGF-β1）或醛固酮诱导的近端小管细胞EMT及肾纤维化。

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3、

jnk may play an important role in the pathogenetic progress of ln in mice, and fluvastatin is able to prevent ln via inhibition of jnk expression in renal tissues in cgvhd mice.

JNK可能参与了狼疮肾炎病情进展，氟伐他汀可能通过影响JNK的表达从而延缓狼疮肾炎肾纤维化进程。

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4、

conclusion: the bioactivity of mmp-2 and timp-1 changes induced by some cytokines which produced and secreting from local vimentin-positive and related cells may play an important role in renal fibrosis of patients with can.

结论：由肾纤维化组织局部Vimentin阳性与相关细胞产生并分泌的细胞因子以诱导MMP-2、TIMP-1的活性改变在慢性肾移植肾病患者的肾纤维化过程中具有关键性作用。

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5、

conclusion measurement of serum level of ha, ln, pc ⅲ and ⅳ-c is of important value for reflection of the degree of hepatic fibrosis, and valuable for diagnosis, treatment and prognosis of diabetic nephropathy.

结论血清中HA、LN、PCⅢ及Ⅳ-C检测可较好地反映糖尿病肾病患者肾纤维化程度，在肾纤维化的诊治及预后方面有较高价值。

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6、

some researches indicated that il-1 is accepted as a potent cytokine for fibrosis of other organs such as heart, gingival tissue, and kidney.

许多研究显示IL-1做为一个强有效的细胞因子，在心脏、齿龈、肾纤维化中发挥重要作用。

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7、

influence of salvianolic acid b on expression of mmp-2 in renal fibrosis rats

丹参酚酸B对肾纤维化大鼠肾组织MMP-2表达的影响

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8、

effect of salvianolic acid b on generation and activation of myofibroblast in rat with renal interstitial fibrosis

丹参酚酸B盐对大鼠肾纤维化的影响

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9、

inhibitory effect of vitamin e on fibrosis of remnant kidney

维生素E对大鼠残肾纤维化的抑制作用

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10、

the relationship between negative regulation factors in ras and renal fibrosis

RAS系统中负向调控因子与肾纤维化的关系

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11、

the former, a film adaptation of a play, won the special jury prize at the siff in 2007;

前一部影片改编自一部戏剧，为他赢得2007年新加坡国际电影节的评委会特别奖；

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12、

mr siff's company, nar test, employs 60 people and is expanding fast.

西弗先生的公司NarTest雇佣了60人，而且正在快速扩张。

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13、

but endel siff, a local businessman, is eager to talk about something else: drug-detection machines.

但是本地商人恩德尔•西弗急于谈论另外一种东西：毒品探测机。

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14、

the short won the best film and special achievement awards at the singapore international film festival (siff) in 2005.

这部短片为他赢得2005年新加坡国际电影节的最佳影片和突出贡献两项大奖。

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15、

objective by observing degree of myocardial fibrosis, changes of vascular endothelium dependent relaxation dysfunction of elderly rats and losartan's intervention effect, to explore the protective effect of angiotensin ii receptor i antagonist on cardiac and arterial aging.

目的观察老龄大鼠心肌纤维化程度、血管内皮依赖性舒张功能不全的变化及洛沙坦的干预作用，探讨血管紧张素II受体I（AT1R）拮抗剂（ARB）对心脏和动脉衰老的保护作用。

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16、

to investigate the value of serum hyaluronic acid ( ha), laminin ( ln) and type ⅲ procollagen ( pc ⅲ) levels in essential hypertensive patients on myofibrosis cordis, two dimensional echocardiography was performed to determine left ventricular mass index ( lvmi).

检测血清Ⅲ型前胶原（PCⅢ）、层粘连蛋白（LN）和透明质酸（HA）的水平与研究其对高血压心肌纤维化患者的临床价值。

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17、

in hcm patients, myocardial fibrosis can cause the late diastolic capacity recovery time delay, but no significant difference between the filling rate with no fibrosis.

在HCM患者中，心肌纤维化可致舒张中晚期容量恢复时间延长，但充盈速率与无纤维化者间无明显统计学差异。

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18、

conclusion: avp stimulates collagen synthesis and no synthesis in neonatal rat cfs, no contents enhancement could inhibit cfs collagen synthesis and myocardial fibrosis induced by avp.

结论：AVP促进CFs胶原合成和NO合成，NO合成增加能够拮抗AVP的促CFs胶原合成作用，延缓心肌纤维化发生。

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19、

conclusions serum level of p ⅲ p is a useful marker reflecting the degree of left ventricular remodeling after ami. collagen response and myocardium fibrosis are reduced after reperfusion of the infarct related artery and left ventricular function preserved.

结论AMI后血清PⅢP浓度的变化是反映左室重构有用的指标，IRA再灌注可以明显减少梗死后的胶原形成，防止心肌纤维化的形成，改善左室功能。

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20、

in order to comprehend better pathological mechanisms of myocardial fibrosis and provide bases for clinical prevention and therapy, the pathomorphological and quantitive changes of the collagen types i and iii were investigated in this study.

本研究通过观察上述心肌纤维化间质I、III型胶原的病理形态改变并定量分析，为深入了解心肌纤维化的病理机制以及临床防治提供依据；

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