efficacy and safety of leflunomide in the treatment of rheumatoid arthritis

1、

an experimental study on the effect of leflunomide in bxsb lupus mice

来氟米特治疗BXSB狼疮鼠的实验研究

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2、

clinical trial on the effect of leflunomide in treating primary membranous nephropathy

来氟米特治疗膜性肾病临床对照研究

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3、

preparation of leflunomide patch and its release characteristics in vitro

来氟米特贴片的制备及体外释药特性

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4、

effects of small dose leflunomide in a long-term treatment of rheumatoid arthritis

小剂量来氟米特治疗类风湿关节炎的远期疗效和安全性

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protective effect of leflunomide to renal tissues in diabetic rats

来氟米特对糖尿病大鼠肾脏的保护作用

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a controlled study on the effect of leflunomide in treatment of iga nephropathy

来氟米特治疗IgA肾病的对照研究

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7、

objective: to establish a hplc method for determination of leflunomide tablets.

目的：建立来氟米特片含量的HPLC测定方法。

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8、

the study of the tolerance of leflunomide in human being

来氟米特人体耐受性试验研究

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9、

the therapeutic effect of leflunomide on the acute chemical liver injury

来氟米特对急性化学性肝损伤的治疗作用

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10、

the action mechanism and advances in clinical application of leflunomide

来氟米特的作用机制及临床应用进展

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11、

application of lime-soil on subgrade surface layer in shuozhou-huangnuagang railway

石灰改良土在朔黄铁路基床表层的应用

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12、

width of the subgrade surface; formation width

路基面宽度

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13、

research on revised subgrade surface deflection with beckman beam

贝克曼梁测试路基表面弯沉修正研究

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14、

technique of controlled rock blasting for widening subgrade surface in deep cutting on electrified double line railway

电气化复线深路堑拓宽石方控爆技术

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15、

dynamic stress is distributed as saddle along the lateral direction of subgrade surface. dynamic stress along the depth declines sharply.

路基面动应力在横向呈马鞍分布，动应力沿深度方向衰减较快。

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16、

wnt signaling, via the activation of the canonical β-catenin and lymphoid enhancer factor/ t-cell factor ( lef/ tcf) pathway, plays an important role in embryogenesis and cancer development by regulating the expression of genes involved in cell proliferation, differentiation and survival.

由β-catenin和LEF/TCF家族转录因子激活的经典Wnt信号通路，通过调控细胞增殖、分化以及存活过程中所涉及的重要基因的表达在胚胎发育和癌症发生过程中起着重要的作用。

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17、

the efficacy rate of group lef+ mtx was 93.8%, 90.6% for group lef, 87.5% for group mtx. the rate of adverse reaction was 31.3% in combination group and 28.1% in lef group, 43.8% in mtx group.

联合用药组和LEF组、MTX组的有效率分别为93.8%、90.6%、87.5%，不良反应发生率分别为31.3%、28.1%、43.8%。

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18、

β-catenin was expressed in the nuclear and cytoplasm in serous malignant oets, which indicated that β-catenin/ apc/ tcf/ lef pathway might be involved in the carcinogenesis of serous ovarian cancers.

卵巢浆液性癌中可见β-catenin在胞核和胞质着色，提示β-catenin/APC/Tcf/Lef通路可能参与了卵巢浆液性癌的发生。

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19、

studies in vitro have indicated that mmp-7 is one of the likely target genes of beta-catenin-tcf4/ lef pathway and that synergistic action of beta-catenin and mmp-7 may play an important role in the carcinogenesis and invasion/ metastasis of crc.

体外实验发现MMP-7可能是β-cat-Tcf4/Lef通路下游靶基因，推测β-cat和MMP-7的协同作用可能在大肠癌的发生和侵袭转移过程中起着重要作用。

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20、

results administration of csa or ctx alone had no appreciable effect on xenograft survival. however, administration of lef alone could significantly prolong the xenograft survival time ( 4.2 ± 1.48? days, p < 0.05 vs group a).

结果单用CsA或CTX不能显著延长移植心脏存活时间，但单用Lef可显著延长移植心脏存活时间达（4.2±1.48）d，与A组比较，P

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