It is well known that the incomplete dedifferentiation and reprogramming of donor nuclei in the oocytes-cytoplasm is the main factors leading to low efficiency in nuclear transfer.

It suggests that epidermal cells occur dedifferentiation to promote wound repair of skin in some conditions. 4.

在皮肤创伤修复过程中，一定条件下表皮细胞可能发生去分化，从而促进创伤修复。

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Objective To investigate the roles of mouse erythroid differentiation and denucleation factor ( MEDDF), newly cloned in our laboratory, in erythroid terminal differentiation.

研究小鼠红细胞分化去核分化因子（MEDDF）在红细胞终末分化中的功能。

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To study the effects of IGF-I on the tendency of growth and de-differentiation of the three-cultured chondrocytes, in order to gain large amount of good type chondrocytes.

研究了解胰岛素样生长因子Ⅰ（IGF-I）对三维培养条件下关节软骨细胞生长和去分化趋势等生物学行为的影响，以期获得大规模生物学性状良好的软骨细胞。

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Gains and Lose Lose Heaven ( 2) The chondrocytes differentiate and lose their special phenotypes gradually with passage.

随着传代培养次数的增加，骺板细胞出现去分化，逐渐失去软骨细胞的特异性表型。

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In addition, silk fibroin has good biocompatibility. It can inhibit cartilage differentiation of cartilage cells.

此外，丝素蛋白是一种生物相容性较好的生物材料，在抑制软骨软骨细胞的去分化方面具有很好的效果。

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Carcinogenesis of primary liver tumor has ever been attributed to dedifferentiation of mature cells; however, recent studies hold that it might be caused by disdifferentiation of hepatic stem cell ( HSC).

原发性肝癌的发生曾归因于成熟细胞的去分化（dedifferentiation），但是，近年来研究认为它可能由肝干细胞（Hepatic stem cell，HSC）分化不全或分化异常（disdifferentiation）所致。

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Conclusion The expressive products of c jun gene was important for VSMC to keep dedifferentiated.

提示C JUN基因表达产物在维持血管平滑肌细胞于去分化状态中起重要作用。

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[ Conclusion] The proliferation of dedifferentiated parietal cells and the reconstruction of oxyntic gland are the histological characteristic of ulcer total healing.

[结论]壁细胞去分化增殖、再分化重构泌酸腺，是胃体溃疡完全愈合的组织学特征。

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The dedifferentiation phenomenon of epidermal cells is approved by the study of animal model of epidermic grafting with eliminating basal layer of epidermis.

在去表皮基底层表皮皮片移植到裸鼠的动物实验模型研究中进一步证实了表皮细胞去分化这一生物学现象存在的可靠性。

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Role of Autophagy in Dedifferentiation of Schwann Cells after Transection of Rat Sciatic Nerve

自噬在大鼠坐骨神经横切后施万细胞去分化中的作用

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Updated Dedifferentiation and Pluripotency of Spermatogonial Stem Cells

精原干细胞去分化和多能性的研究进展

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Experimental study of human adipocyte dedifferentiation for adipose tissue engineering

脂肪细胞去分化及构建组织工程化脂肪的实验研究

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Knockdown of Blimp-1 expression results in plasma cell dedifferentiation

抑制Blimp-1表达导致浆细胞去分化

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Oocytes maturation and in vitro culture systerm are important parts of the embryo engineering and developmental biology. The oocytes reprogramming ability is determined by the degree of maturation.

卵母细胞的成熟和体外培养条件是胚胎工程和发育生物学的重要组成部分，同时也是胚胎体外生产的上游环节，其成熟质量的优劣很大程度上决定了卵母细胞对供体细胞的重编程能力。

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Though it is merely a metaphor, the developmental landscape vividly describes the autonomous hierarchical bifurcation of cellular differentiation and implies the possibility of conversions between different cell types. Therefore, recently it is used extensively as a universal framework to explain both of the development and reprogramming.

虽然它只是一个隐喻，但其形象地描述了细胞的自发的层次分叉过程并隐含了细胞类型之间转换的可能性，从而作为一个整体框架最近被广泛应用来解释细胞发育和重编程。

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IPSCs obtained from embryonic stem cells in the inner cell mass of blastocysts, the nuclear transfered embryonic stem cells and the exogenous transcription factor transferred somatic cells were used to conduct the somatic cell reprogramming research.

通常用来源于囊胚期胚胎的内细胞团的胚胎干细胞、通过核移植得到的胚胎干细胞以及在成体细胞中转入外源转录因子得到的iPSCs，进行体细胞重编程研究。

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It indicates that female fetal fibroblasts are more suitable as donor cells, while th change in the methylation level is not conducive to improve nuclear reprogramming.

这表明雌性胎儿成纤维细胞更适合作为体细胞核移植的供体细胞，而改变其甲基化水平不利于体细胞重编程。

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The high purity of Sertoli cells could eliminate the interference of heterogeneous cell populations in the induction process.

支持细胞分离纯化后可得到高纯度同质性细胞群，排除了异质性细胞群对重编程实验的干扰。

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For the sake of enhancing the effectiveness of mammalian nuclear transplantation, it is necessary to research on how to improve the quality of oocyte after in vitro maturation ( IVM), which is useful for explaining the mechanism of reprogram induced by factors in oocyte cytoplasm;

要提高哺乳动物核移植的效率，不仅要提高卵母细胞体外成熟（IVM）质量，阐明成熟卵母细胞胞质内重编程因子的产生及作用机制；

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However, making the appropriate cells via induced pluripotent stem cells ( iPSCs) requires reprogramming of somatic cells and subsequent redifferentiation.

然而，从IPS细胞制造合适的细胞将需要体细胞的重编程和随后的再分化。

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