histone acetyltransferase

Influence of Histone Acetyltransferase CBP/ p300 on Interleukin-5 Gene Expression Regulation and Its Molecular Mechanisms

组蛋白乙酰转移酶CBP/p300对人白细胞介素-5基因表达调控的影响及其分子机制研究

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Recent studies showed that some transcriptional regulators with histone acetyltransferase ( HAT) and deacetylase ( HDAC) activities may play a causative role in regulating gene expression.

多种具有组蛋白乙酰化酶（HAT）和组蛋白去乙酰化酶（HDAC）活性的调节因子，通过对组蛋白乙酰化过程的调节，在基因表达调控中发挥着重要作用。

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The level of histone acetylation is regulated by the histone acetyltransferase ( HATS) with the acetylation modification of core histone. This further control gene transcription and gene expression regulation which resulted in gene activation or silence.

组蛋白乙酰转移酶（HATs）通过对核心组蛋白进行乙酰化修饰来调节组蛋白的乙酰化水平，从而调控基因的转录，参与基因的表达，并由此介导基因的激活或沉默。

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The nature of chromatin remodeling, the role of histone acetyltransferase and deacetylase, the repression mechanisms of chromatin induced by the methylated CpG binding proteins are discussed in this paper.

本文讨论染色质动态调整的本质、组蛋白乙酰基转移酶和去乙酰基酶的作用、以及通过甲基化CpG结合蛋白而产生对染色质结构影响的机制等。

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Purification and Characterization of Ribosome-Associated Histone Acetyltransferase from Rabbit Reticulocytes

兔网织红细胞乙酰转移酶的纯化及性质研究

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Histone acetylation is an important part of epigenetics. The dynamic equilibrium between Histone acetyltransferase ( HAT) and histone deacetylase ( HDAC) can control the chromatin structure and gene expression.

组蛋白乙酰化修饰是表观遗传学中的重要组成部分，组蛋白乙酰化酶（HAT）和组蛋白去乙酰化酶（HDAC）之间的动态平衡控制着染色质结构和基因表达。

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Objection: The balance between histone acetyltransferase ( HATs) and histone deacetylases ( HDACs) regulates normal cell differentiation and metabolism activity.

目的：组蛋白乙酰基转移酶（HAT）和组蛋白去乙酰化酶（HDAC）的平衡共同调节着正常细胞的分化和代谢行为，而肿瘤的发生往往是二者的失衡所引起的。

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