cisplatin

FDA approved TPT as a treatment drug for small cell lung cancer ( SCLC) and ovarian cancer ( OVC) in 1996. Clinical non cross resistance had been demonstrated between TPT and cisplatin or paclitaxel.

1996年FDA批准治疗小细胞肺癌（SCLC）和卵巢癌（OVC）。临床试验表明，TPT与顺铂和紫杉醇无交叉耐药性。

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Objective: Improving drug burst release and stagnant release of magnetic cisplatin microspheres and achieving controlled release.

目的: 改善磁性顺铂微球的药突释和滞释,实现控释.

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P18~ ( INK4C) depletion aggravates cisplatin-induced acute kidney injury in mice

p18~（INK4C）基因敲除加重顺铂诱导的小鼠急性肾损伤

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OBJECTIVE Study the influence of phosphonomycin on cisplatin renal toxicity.

目的考查磷霉素对顺铂肾毒性的影响.

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FDA approves cisplatin, a powerful anti-cancer drug.

FDA批准一种有效的抗癌药物-顺铂.

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Methods Sixty patients with malignant pleural effusions were randomly assigned to small bore catheter thoracostomy closed drainage group or conventional pleural aspiration group. Cisplatin and interleukin-2 were infused into the thoracic cavity in eligible patients after drainage. Responses were evaluated 30 days later.

方法将恶性胸腔积液患者随机分成两组，分别进行中心静脉导管闭式引流和常规胸腔穿刺，并均于胸腔内注入顺铂（cisplatin，DDP）和白介素2（interleukin2，IL2）。

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Carboplatin , a drug derived from cisplatin, is approved by FDA.

FDA批准顺铂的衍生物-卡铂.

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Survival rates for women with cervical cancer improve when radiotherapy is combined with cisplatin-based chemotherapy.

放疗和 基于 顺铂的化疗联合治疗可以改善宫颈癌患者的生存率.

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Therapeutic Effect of p53 Gene Combined with Cisplatin on Experimental Glioma

p53基因联合顺铂对实验性胶质瘤的治疗作用

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Objective To investigate the protective effect of curcumin ( CMN ) on cisplatin ( CDDP )-induced nephrotoxicity in rats and plausible mechanism.

目的研究姜黄素 ( CMN ) 对顺铂 ( CDDP ) 所致肾损害的防护作用,并探讨其可能机制.

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METHODS: The marketing situation of platinum-containing anticancer drugs, such as cisplatin and car ˉ bop latin, was analysed.

方法: 对顺铂 、 卡铂等几种铂类抗癌药物的市场状况分别加以分析.

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Objective: The absorption, distribution and elimination of microcrystalline cisplatin in mice by oral were studied.

目的: 研究顺铂微晶口服后在小鼠体内的吸收分布和消除情况.

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Objective : To study the preventive actions of ganoderma lucidum polysaccharide ( GLP ) against kidney damage induced by cisplatin.

目的: 研究灵芝 多糖 对顺铂肾毒性的预防作用.

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Objective To investigate the mechanism of cisplatin ( CDDP) inducing premature ovarian failure ( POF, deficiency syndrome of both liver and kidney yin).

目的探讨化疗药顺铂（CDDP）致卵巢功能早衰（POF）肝肾阴虚证的机制。

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In comparison with cisplatin, decreased activation energies were obtained.

与顺铂比较, 发现活化能降低了.

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After cisplatin treatment, experimental cells showed a pronounced S-phase arrest, however, controlled cells with intact wild-type p53, arrested primarily in G2/ M phase.

实验组细胞在给以顺铂治疗后，出现了明显的S期阻滞，而在p53功能完整的对照组细胞却主要出现G2/M期阻滞。

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Cisplatin plus gemcitabine is an appropriate option for the treatment of patients with advanced biliary cancer.

顺铂加吉西他滨是晚期胆道癌病人的一种得当的疗治选择.

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Cell viability was examined by methyl thiazolyl tetrazolium ( MTT) assay and50% inhibitive concentration ( IC50) of cisplatin was examined also.

四甲基偶氮唑蓝比色法检测细胞存活率并计算顺铂的50%抑制浓度（IC50）。

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Chemotherapy plays a pivotal role in the treatment of osteosarcoma. Currently, the main chemotherapy agents for osteosarcoma comprise cisplatin, doxorubicin, ifosfamide and high dose of methotrexate.

化疗在骨肉瘤治疗中的地位举足轻重，当前普遍使用的化疗药物有顺铂、阿霉素、异环磷酰胺及大剂量的甲氨蝶呤。

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In ethological experiment, mice were found obvious pica after injected intraperitoneally cisplatin.

结论：1.在行为学实验中，腹腔注射顺铂后的小鼠出现明显的异食癖现象。

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A key question raised by this patient is whether to use cisplatin or carboplatin.

这一患者带来的关键问题是用顺铂还是用卡铂.

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A549 cells were blocked in G1 phase after treated with cisplatin.

在顺铂作用下，细胞被阻滞于G1期。

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Objective To study the effect of Meglumine ( NMG) on several correlated parameters in rats exposed by cisplatin ( CP), and preliminarily approach its possible mechanism.

目的观察葡甲胺（NMG）预处理对染铂（CP）大鼠肾损害相关指标的影响，初步探讨其预防机理。

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Cisplatin, a heavy metal compound with unique biologic effects, enters clinical trials.

顺铂这一具有独特生物效应的重金属化合物进入临床试验.

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In the two groups, the chemotherapy regimen was PLF ( Cisplatin, Leucovorin and 5-Fluorouracil).

两组化疗均采用PLF（DDP、CF、5FU）方案。

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Superselective renal artery chemotherapy with 150mg/ m ￣ 2 cisplatin followed by embolization was carried out in 8 cases of renal carcinoma.

应用大剂量顺铂150mg／m~2经超选择性肾动脉化疗加碘化油、明胶海绵或钢丝环行肾动脉栓塞术治疗肾癌8例。

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Methods Release the fluid through cavity closed drainage, and inject cisplatin and 5-Fu after the injection of lidocaine and dexamethasone.

方法采用胸腔闭式引流放液，腔内注入顺铂和5-Fu，注药前腔内注射利多卡因和氟美松。

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However, intrinsic or acquired cisplatin resistance is a major therapeutic problem for cancer chemotherapy.

但原发性或获得性顺铂耐药是卵巢癌患者生存率提高的主要障碍之一.

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Objective To observe the kill effect of hyperthermia combined with anti-cancer drugs ( mitomycin, vindesine, cisplatin) on human lung adenocarcinoma cell lines ( D6).

目的观察高温和丝裂霉素（MMC）、长春酰胺（VDS）及顺铂（DDP）联合应用对人肺腺癌细胞的杀伤作用。

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Using molecular modification to reduce the side effect, cisplatin was modified to carboplatin.

透过改造分子结构去减少副作用, 顺铂被改造变成卡铂.

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