cholinergic neuron

AIM: To search the evidences for whether cholinergic neuron is derived from radial glial cell in developing telencephalon, and study the relationship of ontogeny of cholinergic neuron and differentiation of neural stem cell.

目的：为在端脑发育中胆碱能神经元是否来源于放射状胶质细胞寻找实验证据，以分析胆碱能神经元发生与神经干细胞分化之间的关系。

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Conclusions This internal change of acetylcholine may have a relation to injure of islet A cell, indicating that cholinergic neuron may have been regulated by higher level centre, in addition, and been regulated by some endocrine cells too.

结论这种内源性乙酰胆碱的变化可能与胰腺A细胞损伤有关，提示胆碱能神经除受其上级中枢调节外，还受某些内分泌细胞的影响。

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The nucleus basalis of Meynert ( nbM) locates in the base of the forebrain. Almost all of neurons in nbM are cholinergic neuron. Neurofibers sending out from nbM spine into hippocampus, cerebral cortex and other brain regions.

Meynert基底核（nucleus basalis of Meynert，nbM）位于前脑基底部，nbM中的神经元主要是胆碱能神经元，nbM发出的神经纤维投射到大脑皮质广泛区域及海马等部位。

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Study on Cholinergic Neuron Differentiation Induced by Growth Factors from Bone Marrow Stromal Stem Cells and Its Signal Transduction Mechanisms

生长因子诱导骨髓基质干细胞向胆碱能神经元分化及其信号转导机制研究

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The pressor response may be related to the integrity of the function of the cholinergic neuron in the ventrolateral medulla area.

TRH的升压效应可能需要VLM区胆碱能神经元功能的完整。

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The influence of interferon-γ on differentiation of the cholinergic neuron in rat embryonic basal forebrain and septal nuclei

γ-干扰素对大鼠胚胎基底前脑及隔区核团胆碱能神经元分化的影响

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Study on the effect and mechanism of IL-1 β on cultured cholinergic neuron in the rat

IL-1β对培养大鼠胆碱能神经元的影响及机制探讨

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The change of ultra-structure in cerebral cortex microcirculation can induce the dysfunction of cholinergic neuron and further cause the exercise-induced central fatigue.

大脑组织这种形态结构的改变可能导致其神经元功能障碍，进而引起运动性中枢疲劳的发生。

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Substance P like immunoreactive neurons in the cholinergic cortical projection neuron areas of the basal forebrain in the cat

猫基底前脑胆碱能皮质投射神经元区的P物质样免疫反应神经元

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Insulin promotes proliferation of dendrite of the basal forebrain cholinergic neuron

胰岛素促进基底前脑胆碱能神经元树突的增生

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Objective: To observe the protective effect of Panax notoginseng saponins ( PNS) against pathological lesion of cholinergic neuron in rat model with Alzheimer's disease ( AD).

目的：观察三七总皂苷（PNS）对老年性痴呆（AD）大鼠模型大脑胆碱能神经病理损害的保护作用。

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These results suggest that OA neurotoxicity can cause degrading of the learning and memory capability. The possible mechanisms might be related with OA-induced cholinergic neuron damage and function deficit as well as the hyperplasia and hypertrophia of the reactive astrocytes.

以上结果提示：OA的神经毒性可以诱导大鼠学习记忆能力的降低，其可能机制是OA导致胆碱能神经元损伤，功能低下，以及反应性星形胶质细胞的增生肥大。

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Conclusion: PNS plays a protective role in pathological lesion of cholinergic neuron in AD rat model.

结论：PNS对AD大鼠模型大脑胆碱能神经的病理损害具有保护作用。

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DR increases the expression of SYN of cortical and hippocampal neurons by improving the injury of cholinergic neuron to recovery the function of synaptic transmission.

地黄饮子能通过改善鼠脑神经元胆碱能损害，来上调海马和皮层神经元SYN蛋白的表达，使突触传递功能恢复。

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Study on Mechanisms of Generation of Cholinergic Neuron in Developing Telencephalon

在端脑发育中胆碱能神经元发生机制的研究

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Result: By regulating the expression of C-Fos protein, electrotherapy could promote the synthesization of NGF which acts on nourishing and repairing function on cholinergic neuron.

结果：电针可通过调节C-Fos蛋白的表达促进NGF的合成，进而促进胆碱能神经元的营养和修复。

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Study on neural stem cells differentiated into cholinergic neuron induced by NGF

神经生长因子诱导神经干细胞向胆碱能神经元的分化

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The results indicated that down-regulation of PP participated in the loss of cholinergic neuron, formation of NTFs and clinical cognition deficit. It played an important role in the pathogenesis of AD.

本研究结果提示PP活性降低可能参与了神经元纤维缠结形成、胆碱能神经元功能及认知功能障碍，在AD发病机制中起重要作用。

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The change of brain neuropeptide expression and learning ability for aged rat with damaged brain cholinergic neuron system

胆碱能系损伤老化鼠的脑神经肽表达与学习能力改变

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The positive response position of Ach E in cell had changed during mature and differentiation stage of cholinergic neuron, and changed from distribution of initial nucleus to mature cytoplasm.

在胆碱能神经元逐渐成熟的分化过程中ACh E在细胞内的的阳性反应部位发生了变化，由开始时的核膜极其周围分布变化为成熟时的细胞质内分布。

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The characteristic change of pathology in AD were neuritic plaques ( NP), neurofibrillary tangles ( NFTs) and the loss of cholinergic neuron.

主要的病理改变为神经炎斑，神经纤维缠结，胆碱能神经元丢失等。

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