cannabinoid

advances in cannabinoid effects in clinical practice

大麻素类药物的治疗作用

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Cannabinoid ( CB1) receptors are found predominantly in the brain with highest densities in hippocampus, cerebellum and striatum and mainly distributed in presynaptic membrane of never terminals and regulating the release of neurotransmitters.

研究发现CBl受体主要分布于神经系统，以脑组织中表达为主，集中分布在大脑的海马、小脑和纹状体，多定位于神经末梢突触前膜，发挥调节神经递质释放的作用。

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pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test yoon mh, et al

在大鼠福尔马林试验中大麻酯和可乐定或新斯的明的药物相互作用

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regulatory effect of cannabinoid receptors and its ligands on bone mass and remodeling

大麻素受体及其配体对骨量和骨改建的调节作用

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and we learn that the body contains a network of cannabinoid receptors that modulate pain, appetite and short-term memory.

我们也了解到人的身体里有一个大麻成分受体的网络，能够调整痛感，食欲和短期记忆。

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Blocking these cannabinoid receptors reduces hunger and helps people lose weight, the researchers said.

阻断这些大麻素受体可以减少饥饿感,从而帮助人们减肥.

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one promising approach is the use of the selective cannabinoid type 1 receptor antagonist rimonabant.

一个有前途的方法是使用选择性大麻素1型受体拮抗剂利莫那班。

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recently drugs that act on cannabinoid receptors- the ones that mediate marijuana's effects- have been advancing through clinical trials.

最近，作用于大麻素受体的药物也进入了临床试验；大麻素受体是大麻在人体内作用的位置。

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it turns out that there actually cannabinoid receptors in the liver once you have fibrosis.

事实上当发生肝纤维化时肝脏存在大麻素受体。

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it turns out that sweetness receptors are present in the same cells as cannabinoid receptors on our tongues.

原来这是因为我们舌头上甜味的受体与大麻素的受体处于同种细胞里。

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so in fibrotic livers you can find cannabinoid receptors that have both anti- and pro-fibrogenic effects.

因此在发生纤维化的肝脏大麻素受体既有抗纤维化作用也有促纤维化作用。

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rimonabant: a cannabinoid receptor type 1 blocker for management of multiple cardio metabolic risk factors

利莫那班：一种处理复杂的心脏代谢危险因素的大麻素受体1阻滞剂

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rimonabant belongs to the new drug class of cannabinoid-1 receptor antagonists.

利莫那班属于新的药物类大麻-1受体拮抗剂。

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