antisense

Objective The kinetics, affinity and specificity between the human C5a anaphylatoxin and it's antisense peptide R4 was observed.

目的观察生物分子间相互作用动力学、亲和力及特异性，研究C5a与其反义肽的相互作用规律。

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Applying antisense oligonucleotide to block the expression of CLC-3 mRNA .

应用反义核酸的阻断CLC一 3mRNA 在细胞中的表达.

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Biomolecular interactions between sense peptides and its antisense peptides of the human anaphylatoxin C5a

人过敏毒素C5a反义肽与其正义肽的相互作用研究

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Objective: To reveal the possibility of antisense oligonucleotide of telomerase an effective agent for tumor prevention.

目的: 探讨端粒酶反义寡核苷酸对二甲肼诱导大鼠大肠癌的预防作用.

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Tri-helix DNA is the core of the antisense and antigene technology. It control the expression and suppression of gene.

众所周知三链DNA是反基因技术及反义技术的核心，它控制着基因的表达及抑制作用，因此三链DNA也是目前的研究热点之一。

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Objective To study antiviral effect of Lihposome-mediated antisense oligonucleotides COS-ASIN.

目的　研究脂质体介导的反义寡核苷酸在体外对乙型肝炎病毒基因复制和表达的抑制.

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Objective To observe the effect of telomerase antisense oligodexynucleotides on human gastric cancerous cell line.

目的:观察端粒酶反义寡聚脱氧核苷酸对人胃癌细胞株的作用.

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Antisense conformational triggers based on molecular beacons can be used to initiate catalytic events.

基于分子信标的反义构象触发,能开启催化事件.

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Antisense oligonucleotides have been successfully employed to inhibit and modulate specifically gene expression.

反义寡聚核苷酸已成功用于对基因表达的特异性调控与抑制.

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MMP-9 activity was assessed in supernatants from HBECs stably transfected with pEGFPc 1-antisense-ET-1 converting enzyme ( ECE ) RNA.

明胶聚丙烯酰胺凝胶电泳酶谱法检测稳定转染ET - 1转换酶 ( ECE ) 反义核酸上皮细胞培养上清MMP - 9酶活性.

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From Antisense to Antigene: an New Breach of Antigene Strategy

从反义技术到反基因技术：基因治疗的新突破

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Study on the Effects of Hog Cholera Virus Antisense Gene Fragments In Vitro& The specific Inhibition of hog Cholera Virus by Its Antigene Fragments

猪瘟病毒反义基因在培养细胞上的效应研究&反义基因对猪瘟病毒的抑制作用

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Antisense technique is an important area of research in cancer-associated treatment.

反义技术是目前癌症治疗领域很重要的一门技术.

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Objective To find the antagonistic antisense peptides against human C5a anaphylatoxin for exploring interaction between sense peptide and antisense peptide.

目的证实过敏毒素C5a与其反义肽分子间是否确实存在选择性相互识别作用，进一步以反义肽分子设计的思路，寻找过敏毒素C5a拮抗反义多肽的依据。

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Objective To estimate the effort between antisense RNA probe and random primed DNA probe.

目的比较不同方式标记非放射性探针的原位杂交效果.

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There was no effect of the control antisense oligonucleotide on lipoprotein levels or oxidative parameters.

使用反义核苷酸链安慰剂不会引起脂蛋白水平和氧化参数的改变.

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Conclusions Antisense oligonucleotides complementary to CYP3A5 gene may obviously reverse the drug-resistant phenotype of K562/ A02 cells.

结论：针对CYP3A5基因的反义寡核苷酸可显著逆转K562/A02细胞的耐药性。

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On the other hand , antisense oligonucleotide of FAK was used to block its expression.

使用反义寡核苷酸阻断FAK的表达,达到下调信号通路的作用.

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Result After A 549 was infected by recombinant retroviral vector expressing antisense ANG, ANG protein level decreased greatly.

结果　构建出含反义血管生成素的逆转录病毒载体,感染A549细胞后, 能有效抑制A549细胞血管生成素蛋白的表达.

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Objective: In order to explore the effects of CD 40 antisense RNA on Balm cell.

目的: 探讨CD40反义RNA对Balm细胞的影响.

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The classical strategy for antisense therapy is to abrogate abnormal gene expression.

反义治疗的经典策略是阻断异常基因的表达；

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ObjectiveTo investigate the influence of STAT 3 antisense oligodeoxynucleotides ( ASO-STAT 3 ) on radiosensitivity of B 16 cells.

目的探讨反义 STAT3 转染鼠恶性黑色素瘤B16细胞后,肿瘤细胞辐射敏感性的变化.

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Molecular Design of Antisense Peptides for Human C5a Anaphylatoxin and Study on Its Functions

人C5a反义肽的分子设计及其功能研究

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AIM To investigate the effect of vascular endothelial growth factor ( VEGF) antisense gene on the biological characteristics of human gastric cancer cells by antisense nucleotide technique.

目的利用本室构建的反义VEGF165（血管内皮生长因子，Vascular Endothelial Growth Factor）真核表达载体，研究VEGF反义RNA表达对人胃癌细胞生物学表型的影响。

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Cloning and Expression of the Antisense cDNA of the Human C5a Anaphylatoxin in E.coli and Antagonism

人过敏毒素C5a反义cDNA的克隆、表达和拮抗作用

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Until now, several methods have been developed to improve the intracellular delivery of antisense oligonucleotides.

到目前为止, 已发展了数种提高寡聚核苷酸类化合物细胞内转运的方法.

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Liver-targeted gene delivery was often seen in antisense drugs.

基因肝靶向递送多见于反义药物.

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Effect of protein expression on antisense c-myc and PCNA for vascular smooth muscle cells

反义寡核苷酸对血管平滑肌细胞c-myc、增殖细胞核抗原蛋白表达的影响

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In addition, the unique chemical, physical and biological properties of PNAs have been exploited to produce powerful biomolecular tools, antisense and antigene agents, molecular probes and biosensors.

此外，鉴于肽核酸独特的理化和生物学性能，人们正尝试将其用于生物分子工具、反义和反基因制剂、分子探针和生物传感器。

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The sequencing result of antisense DNA fragment was in accordance with the known LMP 1 gene.

结果:酶切产物和PCR产物 的凝胶电泳显示400bp左右的目的基因片段,测序结果显示与已知LMP1基因序列一致.

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