abortifacient

Effect of structural modification of trichosanthin on its abortifacient activity

天花粉蛋白结构改造对引产活性的影响

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Abortifacient effects of mifepristone combined with water bag and rivanol were observed in 187 cases.

目的:观察187例口服米非司酮联合水囊引产及联合利凡诺引产的临床疗效.

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Pinellin can be used as an abortifacient protein for terminating early pregnancy of mice.

半夏蛋白曾作为抗早孕蛋白，用于终止小鼠的早期妊娠。

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Aim: To study the effect of structural modification on the abortifacient activity of trichosanthin.

目的：研究结构改造对天花粉蛋白（TCS）引产活性的影响。

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Methods: Glutamine residue in 219 of trichosanthin was mutated into cysteine residue ( Q219C) by site-directed mutagenesis. The mutein was then modified by polyethylene glycol ( PEG). Ribosome-inactivating activity and abortifacient activity of the modified products were determined.

方法：利用定点突变将TCS第219位的天冬酰胺残基改变为半胱氨酸残基（Q219C）以供定点聚乙二醇（PEG）修饰，测定修饰产物的致核糖体失活活性及小鼠中期引产活性。

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Trophoblast cells isolated from Human Villi of early pregnancy and Study on Mechanism of abortifacient effect by Verbena officinalis

人早孕绒毛滋养层细胞的分离纯化及马鞭草抗早孕机理的初步研究

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There was no significant change in abortifacient activity by 5 000 PEG modification, whereas the activity was significantly enhanced when TCS was modified by 20 000 PEG.

相对分子质量为5000的PEG修饰对引产活性无明显影响，而相对分子质量为20000的PEG修饰却明显增强引产活性；

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Model drug mifepristone was an effective abortifacient.

模型药米非司酮，是一种临床常用的抗早孕药物。

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To study the mechanism of abortifacient effect of extract of Verbena officinalis ( VO), trophoblast cells from human placenta of 6 ￣ 8 weeks early pregnancy was isolated with Percoll method and cultured in vitro.

正常妊娠6～8周人绒毛滋养层细胞以Percol分离、纯化及体外培养为实验手段，观察马鞭草提取液对滋养层细胞功能的影响，进一步探讨了马鞭草抗早孕的细胞学作用机理。

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