aav

Conclusion AAV-mediated striatal transgene expression of TH, AADC and GCH is more effective for gene therapy on Parkinsonian rat.

结论AAV载体介导的TH、AADC和GCH三重基因纹状体内共表达对于帕金森病大鼠的基因治疗更为有效。

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The bioactive AAV-hVEGF _ ( 165 ) was packaged by Benyuan Zhengyang Corporation, and the AAV-hVEGF _ ( 165 ) was successfully constructed.

本元正阳公司包装出具有生物学功能的AAV-hVEGF_ ( 165 ),AAV-hVEGF_ ( 165 ) 构建成功.

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The AAV virus with high-purity, high enrichment and high titer are got though protein electrophoresis detection and virus electric mirror picture.

通过蛋白电泳检测及病毒电镜图片显示最终得到高纯度、高浓缩、高滴度的AAV病毒。

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The NIH 3 T 3 infected rGFP-AAV expressed significantly GFP fluorescence, which showed that rGFP-AAV was infectious virions.

感染了重组 GFP -AAV的大鼠NIH3T3细胞表达了明显的GFP荧光.

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Low level of anti-HSV and anti-AAV antibodies was detected in mouse serum.

小鼠血清中可以检测到少量 抗 HSV抗体和 抗 AAV抗体.

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After 3 weeks, AAV-hTGF-� � _ 1 was injected into groups D injury intervertebral discs.

3周后, D组椎间盘显微注射AAV-hTGF-1β.

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But AAV can cause non-specific infections because of its wide host range and thenon-specific expression of carried target gene can lead to off target or immune response, which limits its usage in the gene therapy.

但是在AAV作为载体使用时，由于其宿主广而引起非特异的感染以及对携带的目的基因非特异的表达会引起脱靶甚至免疫反应，使其在基因治疗中受到了限制。

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Results 1. The recombinant AAV expressing human VEGF 121 gene wassuccessfully constructed and confirmed by DNA sequencing.

结果:1、成功构建了rAAV-VEGF,经序列测定目的基因为VEGF_(121).

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Conclusion The triple transduction of TH, AADC and GCH genes with separate AAV vectors is effective, which might be important to gene therapy for Parkinson's disease.

结论使用AAV载体进行TH、AADC、GCH三重基因共转导是有效的，这对帕金森病基因治疗的研究具有重要意义。

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Besides, AAV also has outstanding performances in nervous system diseases, metabolic diseases, as well as tumors.

除此之外，AAV在神经系统疾病、代谢疾病以及肿瘤等应用中都有着较好的表现。

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The safety of intramuscular injection of recombinant adeno-associated virus ( AAV )-mF to rescue hemophilia B was assessed.

研究了肌注腺伴随病毒 ( adeno-associatedvirus,AAV ) 介导凝血因子基因治疗血友病B的安全性.

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Objective Plasmid of AAV vector with HIV 1 gag and gp 120 were constructed respectively.

目的构建带有HIV1gag或gp120基因的重组腺病毒伴随病毒AAVHIVgag或AAVHIVgp120.

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This may be assessed by means of the aggregate abrasion value ( AAV ) test.

这种能力可以通过聚合物磨损值 ( AAV ) 测试来评估.

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Protection mechanism of mice transferred by AAV 2-BPI_ ( 700)-Fc γ 1_ ( 700) recombinant virus to minimal lethal dose E.coli infection

AAV2-BPI（700）-Fcγ1（700）重组病毒导入小鼠对致死量大肠埃希菌感染的保护作用机制

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