UUO

Conclusion Adrenomedullin play an important role in the process of cell proliferation in renal interstitial pathological changes by UUO.

结论肾上腺髓质素在UUO介导的肾间质病变的细胞增殖过程中有着重要的作用。

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METHODS: Animal were randomly divided into sham-operated ( SHAM ) , UUO and UUO administration with RSG ( UUO + RSG ), respectively.

方法: 将大鼠随机分成UUO组和UUO+RSG组,另设假手术组 ( SHAM ) 为对照.

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The models were established by unilateral ureteral obstruction ( UUO) of the left side.

以单侧输尿管结扎术建立输尿管梗阻的动物模型。

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High estrogen group ( rats underwent UUO and received 17 β-estradiol injection).

高雌激素组（UUO+E2）。

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Protective Effect of Recombinant Human Erythropoietin in Renal Tubulointerstitial Fibrosis with UUO in Rat

重组人红细胞生成素改善UUO大鼠肾脏纤维化的研究

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Low estrogen group ( rats were ovariectomized and underwent UUO);

低雌激素组（UUO+OVX）；

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[ Conclusion] Oxidation stress contributes in UUO induced renal interstitial fibrosis.

结论单侧输尿管梗阻可以诱导大鼠肾间质纤维化，氧化应激参与肾间质纤维化的形成。

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Conclusion The pharmacological effects of curcumin and enalapril may be partly mediated by inhibiting the transdifferentiation of renal tubular epithelial cells towards myofibroblast in UUO rats.

结论姜黄素及依那普利可能通过抑制UUO大鼠肾小管上皮细胞转分化而减轻肾间质纤维化。

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Six rats of each group were killed respectively at 1,4,7,10,14 days after UUO.

于术后第1，4，7，10，14天分别处死各组大鼠。

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[ Objective] To evaluate the effect of estrogen on tubular epithelial cell phenotype transdifferentiation of tubulointerstitial fibrosis in unilateral ureteral obstruction ( UUO) rats.

目的探讨雌激素在单侧输尿管梗阻（UUO）大鼠肾间质纤维化模型中对肾小管上皮细胞表型转化的影响。

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