EAE

Methods: The female guinea pigs were divided randomly into group, EAE group and p . MBP group.

方法将雌性豚鼠随机分为对照组 、 EAE组 和腹腔注射MBP组.

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We found there were multiple inflammatory cells in the brain and spinal cords in EAE mice, and the demyelination changes in the white matter were evident.

光镜下可见小鼠脑和脊髓组织中有大量的炎性细胞浸润，并伴有明显的白质脱髓鞘改变。

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Results Group TRD 3 ( 40 g TRD · rat-1· d-1 ) implies a therapeutic effect.

结果TRD在每只鼠每日40g剂量下影响EAE大鼠 MCP-1mRNA的表达.

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Objective Establishing experimental autoimmune encephalomyelitis ( EAE) model in insensitive Wistar rats from Shanxi Medical University to observe expression of MCP-1 mRNA.

目的探讨Wistar大鼠诱导实验性变态反应脑脊髓炎（EAE）动物模型，检测EAE中起关键趋化作用的巨噬细胞趋化因子-1（MCP-1）的表达。

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The genes related to immune, cell structure, cell cycle, ion chanal, signal transduction, protein synthesis and metabolism involved in EAE pathogenesis.

（二）除免疫相关基因外，细胞结构相关基因，能量代谢相关基因，蛋白质合成相关基因，细胞周期相关基因，离子通道相关基因等参与了自身免疫性脑脊髓膜炎的发病。

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OBJECTIVE: To find a possible method to inhibit or interdict EAE pathologic process to speed up the restorative course for neural function.

目的：寻求一种可能抑制或阻断EAE病理过程，加速神经功能恢复进程的方法。

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However, the activation of microglia in acute episode of EAE was most obviously.

小胶质细胞的活化增殖在EAE急性期表现最为明显，缓解期和复发阶段均有活化现象的存在；

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Objective: To induce a meliorative model of experimental allergic encephalomyelitis ( EAE).

目的：提取并纯化正常人脑脊髓的髓磷脂碱性蛋白（MBP），鉴定其活性，并用其诱导实验性自身免疫性脑脊髓炎（EAE）大鼠模型。

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Experimental autoimmune encephalomyelitis ( EAE ) is a well-known animal model for studying multiple sclerosis ( MS ) in humans.

实验性自身免疫性脑脊髓炎 ( EAE ) 是公认的研究人类多发性硬化 ( MS ) 的动物模型.

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IFN-τ can prevent the development of experimental allergic encephalomyelitis ( EAE), an animal model for multiple sclerosis ( MS) in humans.

实验性变应性脑脊髓炎（EAE）是多发性硬化症（MS）的动物模型。IFN-τ能够抑制实验性脑脊髓炎的发生、发展。

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Conclusion EAE is characterised by perivascular inflammatory cell infiltration and demyelination in white matter.

结论EAE的病理改变主要为血管周围炎性浸润及白质脱髓鞘.

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Aim : To explore the therapeutic effect of MCI-186 on experimental autoimmune encephalomyelitis and its mechanism.

目的: 探讨MCI-186干预实验性自身免疫性脑脊髓炎(EAE)的疗效及机制.

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Objective : To induce the EAE model on Guinea pig wi th Myelin Basic Protein ( MBP ).

目的: 用髓鞘碱性蛋白 ( MBP ) 诱导实验性变态反应性脑脊髓炎(EAE)豚鼠模型.

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