BHB

Objective To investigate the effect of PEG-conjugated bovine hemoglobin ( PEG-bHb) on mean arterial pressure, colloid osmotic pressure ( COP) and p50 when added directly to CPB prime in anaesthetized rabbits.

目的探讨在体外循环（CPB）预充液中加入聚乙二醇牛血红蛋白偶联物（PEG-bHb）对兔平均动脉压（MAP）、胶体渗透压（COP）及p50的影响。

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The calculation of far-UV CD data showed that the secondary structure of BHb had slight changes, and the α-helical content was decreased.

拟合计算远紫外CD数据发现，银纳米粒子诱导BHb产生轻微的二级结构改变，α-螺旋含量降低。

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Objective Based upon the results of experiments on animals, to conjecture the immunological responses after infusion of polymerized bovine hemoglobin ( poly BHb) in humans.

目的通过动物实验，推导人造血液基质聚合牛血红蛋白（poly BHb）输入人体后可能引起的免疫反应。

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Conclusion The preparation of erythrocyte substitute by modifying bHb with mPEG is worth of further study.

结论尽管还有很多问题需要解决，mPEG修饰牛血红蛋白制备红细胞代用品具有深入研究的价值。

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