1、

Objective To study the effect of hypoxia-inducible factor-1 α( HIF-1 α) on angiogenesis and endothelial progenitor cell ( EPCs) mobilization during tissue ischemia.

目的探讨低氧诱导因子1α(HIF-1α)在组织缺血时血管生成及内皮祖细胞(EPCs)动员中的作用。

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Conclusions HIF-1 α antisense oligonucleotide can inhibit angiogenesis and circulating endothelial progenitor cell mobilization in rat hind limb ischemia through regulating role of the VEGF. HIF-1 α is a mobilization factor of EPCs during tissue ischemia.

结论全硫代修饰HIF-1α反义寡核苷酸可抑制大鼠缺血肢体血管生成和因缺血引起的EPCs的动员,其机制可能是通过VEGF起作用,HIF-1α是组织缺血时EPCs一个动员因子。

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Therefore, it is of great significance to strengthen the expression of HIF-1 in hypoxia circumstance to protect neuron. Neuroglobin ( Ngb) is a kind of grade ischemic induced nervous tissue protein, mainly existing in retina and brain.

因此在低氧条件下促进HIF-1的表达对神经元的保护有重要意义。神经珠蛋白(Neuroglobin,Ngb)是一种缺血诱导的神经组织蛋白质,主要分布于视网膜和大脑。

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HIF-1a expression and correlation to clinical-pathological factors in squamous cell carcinoma of the tongue

舌鳞状细胞癌HIF-1a与临床病理因素的相关性分析

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Expressions and Significance of HIF-1 α in Human Tongue Squamous Cell Cacinoma Tissue

HIF-1α在人舌鳞癌组织中的表达及意义

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Results The expression of HIF-1 α in NHL patients with intermediate or high grade, low grade and lymph nodes of reactive hyperplasia was 0.291 ± 0.082 、 0.154 ± 0.045 、 0.046 ± 0.018, respectively, the difference was statistically significant ( P < 0.05).

结果HIF-1α在中-高度恶性NHL组、低度恶性NHL组和反应性增生淋巴结中的表达分别为0.291±0.082、0.154±0.045、0.046±0.018,各组间比较差异有统计学意义(P

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Conclusion The differential expression of the three HIF-α subunits may play a role in the development of hypoxia-induced pulmonary hypertension.

结论3种HIFα表达差异可能在缺氧性肺动脉高压发病中发挥作用。

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The Role of Expression of HIF-1 α mRNA in Lung Carcinoma on Tissue Microarray

HIF-1αmRNA在肺癌组织芯片中的表达意义

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Prokaryotic expression and polyclonal antibody preparation of plateau pika HIF-1 α protein

高原鼠兔低氧诱导因子-1α蛋白的原核表达及多克隆抗体的制备

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Effect of Intense Hypoxia Training on Glycolysis Enzymes Activity and HIF-1 α Expression in Rat Skeletal Muscles

低氧高强度训练下大鼠骨骼肌糖酵解酶活性和HIF-1α表达的变化

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Design of a hammerhead ribozyme targeting HIF-1 α mRNA and cloning of its gene

抗HIF-1αmRNA锤头状核酶设计及其基因克隆

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Expression and significance of VEGF and HIF-1 α in endometriosis and adenomyosis

VEGF和HIF-1α在子宫内膜异位症及子宫腺肌症中的表达及其意义

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Objective: To investigate the effects of exhaustive exercise on HIF-1 α protein expression, NOS activity and NO level of mice's brain during" living high-training low"( HiLo).

目的:了解高住低训下力竭运动对小鼠大脑内HIF-1蛋白表达和NOS/NO系统的影响。

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HiLo could induce mRNA expressions of HIF-1 α and VEGF in the gastrocnemii, but the increasing trend with time course was different.

高住低训能诱导腓肠肌HIF-1α和vEGF mRNA表达,但其升高趋势会因时间差异而不同。

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Our results demonstrated that HIF-1 α expression increased during APAP or D-GalN/ LPS induced acute liver failure.

本实验结果显示对乙酰氨基酚、D-氨基半乳糖联合内毒素诱导的急性肝衰竭时HIF-1α表达增加。

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Conclusion Exogenous NGF reduced VEGF and HIF-1 expression in the sciatic nerves of diabetic rat.

结论局部应用外源性NGF减少糖尿病大鼠坐骨神经VEGF和HIF-1的表达。

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Correlation of expression of HIF-1 α with MDR-related factors and chemosensitivity in gastric carcinoma tissues

胃癌组织HIF-1α表达与多药耐药因子及体外化疗药敏性的关系

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AIM: To investigate the relationship between the expression of hypoxia-inducible factor-1 α ( HIF-1 α) and myocardial angiogenesis induced by hypoxic preconditioning ( HPC).

目的:研究低氧诱导因子-1Α(HIF-1Α)在低氧预处理(HPC)诱导心肌血管生成中的作用,并探讨其细胞信号转导的机制。

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Objective: To evaluate clinical significance of HIF-1 α、 VEGF and VEGF-C expression in papillary thyroid carcinoma.

目的:探讨甲状腺乳头状癌中缺氧诱导因子-1α(HIF-1α)、血管内皮生长因子(VEGF)和VEGF-C表达的临床意义。

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Correlation of HIF-1 α and VEGF Expression with the Angiogenesis of Papillary Thyroid Carcinoma

甲状腺乳头状癌中HIF-1α、VEGF表达与血管生成的关系

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