bcr/ abl-based novel therapeutic strategies in chronic myelogenous leukemia treatment

1、

among the 35 cases of mature b-cell malignancies, 17 cases of chronic lymphocytic leukemia/ small lymphocytic lymphoma ( cll/ sll) mainly expressed cd19, cd20, cd5, hla-dr, with coexpression of cd19 and cd5;

成熟淋巴细胞肿瘤35例，其中17例慢性淋巴细胞白血病/小淋巴细胞淋巴瘤主要表达CD19、CD20、CD5和HLA-DR，并有CD19与CD5共同表达。

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2、

objective to explore the effects of various factors affecting apoptosis of chronic lymphocytic leukemia ( cll) cells mediated by p2z purinoceptor.

目的探讨嘌呤能P2Z受体介导慢性淋巴细胞白血病（CL L）细胞凋亡的影响因素及其机理。

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3、

objective to study the rearrangement of bcl 1 gene ( bcl 1/ igh gene rearrangement) in b cell chronic lymphocytic leukemia, and its clinical signification.

目的探讨Bcl-1基因重排（即Bcl-1/IgH基因重排）在B细胞慢性淋巴细胞白血病中的发生情况及其临床意义。

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4、

overexpression of bcl-2 has been observed in b-cell lymphoma, b-cell acute lymphoblastic leukemia ( b-all), b-cell chronic lymphocytic leukemia ( b-cll) and correlates closely with the occurrence, progress, recurrence and multidrug-resistance of these malignancies.

Bcl-2高表达见于B细胞淋巴瘤、B细胞急性淋巴细胞白血病、慢性淋巴细胞白血病等血液系统恶性肿瘤，与这些肿瘤的发生、发展、复发、耐药密切相关。

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5、

cd40 is widely expressed on b lymphocytes, monocytes/ macrophages, dendritic cells, hematopoietic cells, epithelial cells, vascular endothelial cells as well as carcinoma cells.

CD40主要表达于B细胞、单核/巨噬细胞、树突状细胞、造血细胞、上皮细胞、血管内皮细胞及一些肿瘤细胞（如急慢性淋巴细胞白血病，霍奇金淋巴瘤，鼻咽癌，乳腺癌等）也有表达。

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6、

chromosome study on chronic lymphocytic leukemia using cpg-odn as immunostimulant agent

应用CpG-ODN免疫刺激进行慢性淋巴细胞白血病的染色体研究

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7、

conclusions bcl 1 rearrangement is often present in b cell chronic lymphoproliferative leukemia.

结论（1）B细胞慢性淋巴细胞白血病常发生Bcl-1基因重排，骨髓正常者未检出Bcl-1/IgH基因重排。

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8、

it is found on b-cell lymphomas, hairy cell leukemia, b-cell chronic lymphocytic leukemia, and melanoma cancer stem cells.

CD20在B细胞淋巴瘤、毛细胞白血病、B细胞慢性淋巴细胞白血病和黑色素瘤肿瘤干细胞中均被发现。

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9、

zap-70 expression in 24 patients with b cell chronic lymphocytic leukemia

ZAP-70在24例B细胞慢性淋巴细胞白血病中的表达研究

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10、

results the bone marrow mvd [ ( 21.48 ± 8.50)/ hpf] of the newly diagnosed acute and chronic leukemia patients was significantly higher than that of the control group [ ( 9.29 ± 3.53)/ hpf] ( p < 0.01).

结果初诊急慢性白血病患者骨髓MVD[（21.48±8.50）/hpf]明显高于对照组[（9.29±3.53）/hpf]（P

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11、

the results indicate that s-asp determination may have diagnostic and monitoring value on the patients with leukemia, malignant lymphoma and multiple myeloma.

结果表明，血清酸溶性蛋白测定在急慢性白血病、恶性淋巴瘤和多发性骨髓瘤的诊断和病情监测上有一定的临床实用价值。

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12、

objective: to explore the value of bone marrow biopsy in diagnosing acute and chronic leukemia with reticulin myelofibrosis.

目的：评估骨髓活检在急、慢性白血病继发网硬蛋白纤维化时的诊断价值。

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13、

objective to investigate the role of angiogenesis in acute and chronic leukemia and its correlation with clinical condition.

目的探讨急慢性白血病患者骨髓血管新生情况与临床病情的关系。

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14、

expression of anti-angiogenesis factor endostatin in acute and chronic leukemia

血管生成拮抗因子内皮抑素在急慢性白血病中的应用研究

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15、

conclusion there was tumour angiogenesis in acute and chronic leukemia.

结论急性、慢性白血病存在肿瘤性血管新生。

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16、

doxorubicin ( dox) is an anthracycline antibiotic, it is one of the most effective and important anticancer agents widely used in the treatment of a variety of human cancers including acute leukaemia and malignant lymphoma as well as a number of solid tumor.

阿霉素（Doxorubicin，DOX）为临床常用的广谱、高效抗肿瘤药物，广泛用于急慢性白血病、各种实体瘤等多种癌症的化疗。

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17、

objective to evaluate the clinical efficacy against acute and chronic leukemia of unrelated donor allogenetic marrow transplantation ( urd-bmt) and to develop methods of preventing and treating complications of urd-bmt.

目的评价非亲缘异基因骨髓移植（URD BMT）治疗急性和慢性白血病的临床疗效以及并发症的防治方法。

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18、

to analyze microsatellite instability ( msi) and loss of heterozygosity ( loh) at 8 loci of different chromosomes from 17 chronic leukemic patients and 11 health volunteers with polymerase chain reaction ( pcr) technology.

应用PCR扩增技术检测17例慢性白血病患者不同染色体上8个微卫星位点的微卫星不稳定性（MSI）和杂合性缺失（LOH），同时检测11例健康志愿者的MSI和LOH，以作对照。

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19、

objective to observe the therapeutic efficacy and safety of donor leukocyte infusion ( dli) in acute, chronic leukemia and multiple myeloma.

目的观察供体白细胞输注（DLI）治疗急慢性白血病和多发性骨髓瘤的疗效和安全性。

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20、

the adenosine deaminase ( ada) activity was measured with colorimetric analysis in the plasma from 63 patients with acute and chronic leukemia.

采用比色法测定了63例急慢性白血病患者血浆腺苷脱氨酶（ADA）活性。

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