a mechanism study of sophorcarpidine in treatment of pancreatic fibrosis

expression of angiotensin ii receptors after pancreatic fibrosis in rats

血管紧张素Ⅱ受体在胰腺纤维化大鼠胰腺组织中的表达及其意义

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increasing evidences suggest that oxidative stress and lipid peroxidation have tight relation with pancreatic fibrosis. they not only induce pancreatic cell damage directly, but also can activate pscs, so promote the fibrotic process.

越来越多的研究显示胰腺纤维化的发生发展与氧化应激、脂质过氧化等有关：氧化应激不仅能够直接导致胰腺细胞损伤，还能激活PSCs，加速纤维化进程。

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in conclusion, oxidative stress, activation of pscs and cytokines are the important mechanisms of pancreatic fibrosis and they interact.

氧化应激、PSCs活化和细胞因子是胰腺纤维化的重要机制，三者之间存在交互作用。

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conclusions losartan alleviates tnbs-induced pancreatic fibrosis in rats, suggesting that rennin-angiotensin system might be one of the important contributors for formation of pancreatic fibrosis.

结论1型血管紧张素Ⅱ受体拮抗剂对TNBS诱导的大鼠胰腺纤维化形成具有抑制作用，表明肾素血管紧张素系统（RAS）在慢性胰腺炎胰腺纤维化的发生发展过程中起重要的介导调节作用。

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progressive fibrosis is a characteristic feature of chronic pancreatitis, and pancreatic stellate cell plays an important role in the fibrotic progression of pancreas.

胰腺纤维化是各类慢性胰腺炎的共同特征，胰腺星状细胞（PSC）在胰腺纤维化进程中起重要作用。

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pancreatic fibrosis was induced by intraperitoneal injection with diethyldithiocarbamate ( ddc 750 mg/ kg body weight) in rats.

以腹腔注射DDC（750mg/kg体重）每周2次，共6周建立胰腺纤维化动物模型，治疗组于DDC注射后2周起每日腹腔注射苦参碱（100mg/kg体重），6周后处死动物。

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conclusion: pancreas fibrosis can be inhibited by ptx in rats.

结论：PTX有抗大鼠胰腺纤维化的作用。

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objective to investigate the expression of angiotensin ⅱ receptors in pancreatic tissue and to clarify their effects on development of pancreatic fibrosis in rats.

目的动态观察血管紧张素II受体在胰腺纤维化大鼠胰腺组织中的表达并探讨其可能意义。

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expression of pdgf and its receptor on pancreas fibrosis in rats

PDGF及其受体在大鼠胰腺纤维化中的作用

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activated pscs have been identified as an important cellular source of ecm in pancreatic fibrosis.

活化的PSCs是胰腺纤维化过程中胶原产生的重要来源。

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roles of nuclear factor-κ b in the development of rat pancreatic fibrosis mediated by angiotensin ii

核因子-κB在血管紧张素II介导的大鼠胰腺纤维化发生中的作用

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objective to study the effects of high glucose dialysate on proteins secreted by human peritoneal mesothelial cells ( hpmcs), and to analyze the effects of proteins on peritoneal fibrosis and peritoneal functions by proteome methods.

目的研究腹透液中葡萄糖对人腹膜间皮细胞（HPMCs）分泌蛋白质影响，并采用蛋白质组学方法分析其对腹膜纤维化和腹膜功能的影响。

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objective to investigate the relationship between the changes of nuclear transcription factor sp1 activity, type ⅰ collagen α 1 ( col1a1) and tissue inhibitor of metalloproteinases 1 ( timp 1) protein expression in peritoneal tissue after operative trauma of human and peritoneal fibrosis.

目的探讨人手术创伤腹膜组织中核转录因子Sp1激活，COL1A1和TIMP1表达变化与腹膜纤维化之间的关系。

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conclusion indomethacin can inhibit the synthesis and secretion of extracellular matrix in human peritoneal mesothelial cells, which may be effective in the gene therapy for peritoneal fibrosis.

结论：吲哚美辛可抑制人腹膜间皮细胞合成细胞外基质，在腹膜纤维化的防治中有潜在的应用价值。

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molecular mechanism of peritoneal fibrosis in peritoneal dialysis.

腹膜透析相关纤维化的分子机制。

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objective to compare different types of peritoneal fibrosis models in rats.

目的：采用几种不同方法构建腹膜透析腹膜纤维化大鼠模型，为腹膜透析腹膜纤维化的防治提供可研究的动物模型。

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28 cases post-renal arf resulted from tumors, stones, benign prostatic hypertrophy, fibrosis of post-peritoneal, malformation and neurogenic bladder.

肾后梗阻性ARF28例（9.7%），病因为肿瘤、结石、前列腺增生、腹膜后纤维化、泌尿系畸形、神经性膀胱。

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to investigate imaging findings of retroperitoneal fibrosis and their values for diagnosis.

摘要探讨腹膜后纤维化的影像学表现及其诊断价值。

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conclusion the final diagnosis of rpf depends on pathology and surgery.

结论腹膜后纤维化确诊需经手术和病理。

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objective to investigate the clinical characteristics of idiopathic retroperitoneal fibrosis.

目的加深对特发性腹膜后纤维化临床体征的认识，提高早期诊断的水平。

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