In this dissertation, a series of plumbagin derivatives have been obtained through the structural modification of active constituent plumbagin from traditional Chinese medicine ( TCM). Their antitumor activity, interaction with DNA, Topo ⅰ, Topo ⅱ have been investigated.

1、

Conclusion: Plumbagin could significantly inhibit the growth of T-24 cells by suppressing proliferation and inducing cell apoptosis, which lays the groundwork for further investigation into the mechanisms of anti-tumor effects of Plumbagin.

结论：白花丹素能通过抑制细胞增殖，诱导细胞凋亡对膀胱癌T24的生长发挥明显的抑制的作用。本研究为进一步研究白花丹素抗癌机制奠定了基础。

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Although plumbagin and its metal complexes exhibit good antitumor activity, the high toxicity and poor water solubility limit the bioavailability and the possibility of being as medicine.

虽然白花丹素及其金属配合物显示出较好的体外抑瘤活性，但由于它们具有较高的毒性、较差的水溶性限制了其生物利用度和成药可能性。

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Determination of plumbagin in different parts of Plumbago zeylanica by RP-HPLC

RP-HPLC测定民族药材白花丹不同药用部位中白花丹醌的含量

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Objective: To explore the growth inhibition and apoptosis inducing effects of Plumbagin on human bladder cancer T-24 cell line.

目的：研究白花丹素对膀胱癌的生长抑制和诱导细胞凋亡的作用。

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RESULTS: Plumbagin decreased the content of GSH on Kasumi-1 cells.

结果：（1）白花丹醌可以降低细胞内GSH的含量。

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In vitro nephrotoxicity of plumbagin and protective effect of acid fibroblast growth factor

白花丹素的体外肾毒性及酸性成纤维细胞生长因子对白花丹素所致肾损伤的保护作用

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Effects of Plumbagin on the Human Acute Promyelocytic Leukemia Cells In Vitro

白花丹醌对人急性早幼粒细胞白血病细胞的体外效应

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It is concluded that for the first time the present study shows that plumbagin can inhibit cell proliferation, block cell cycle and induce apoptosis of APL cell line NB4 cells.

结论：本研究首次证实白花丹醌能够抑制APL细胞系NB4的增殖、诱导细胞凋亡及阻滞细胞周期进程。

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Population Density, Population Capacity, Population Pressure

人口密度·人口容量·人口压力

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Among countries with high population density

在人口稠密的国家里

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Spatial Continuous Surface Model of Population Density

人口密度的空间连续分布模型

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Survey and Analysis on Variety of the Flies Population Density in Shanghai

上海中心老城区蝇类种群密度变化分析

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Studies on the model of forest population density change during self-thinning

森林自疏过程中密度变化规律的研究

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Discussions on the rate equation of level population density

对于计算能级占据数密度的速率方程的一些讨论

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On Chengdu's Population Density Distribution and the Influencing Factors

成都市人口密度分布差异的影响因素

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But there are linear correlation between population density and mean age.

种群密度与平均年龄有线性相关。

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The population density decreases with the increase of diameter class.

种群密度随径级增大而减小。

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Digital Simulation of Population Density in China

中国人口密度数字模拟

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Spatial autocorrelation method used for the estimation of insect population density

昆虫种群密度估计的空间自相关方法

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Analysis of conversion and characteristics of fresh air volume in high population density building

高密人群建筑新风量指标的转变与特征分析

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