High degree of genetic and clinical heterogeneity makes RP very complex. The mode of heritance can include autosomal dominant, autosomal recessive, X-linked, digenic and sporadic.

Additionally, because genetic heterogeneity is present among tumor cells and the gene expression may vary from the primary lesions to the metastatic lesions, false negative results are likely to occur when micrometastasis is detected using a single marker.

另外，由于肿瘤细胞存在基因异质性，原发灶和转移灶的基因表达可能不一致，因此单标志物检测微转移容易出现假阴性。

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In the view of molecular genetics, there is considerable genetic heterogeneity in retinitis pigmentosa ( RP), suggesting that the same gene in different countries or ethnic groups, with differences in their pathogenicity.

在分子遗传学角度上，视网膜色素变性（RP）存在相当大的遗传异质性，提示同一个基因在不同的国家或种族中，其致病性具有差异性。

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There exist differences in characterization of coronary heart disease with blood stasis. The differences may be related to hereditary factors, prompted that coronary heart disease with blood stasis syndrome essence may be genetic heterogeneity. 3.

冠心病血瘀证的表征存在着差异，这种差异可能与遗传因素有关，提示冠心病血瘀证的证本质可能存在遗传异质性。

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However, due to the large size of many genes and genetic heterogeneity of many diseases, the Sanger sequencing technology has been far from satisfying the needs of scientific research and clinical applications.

但由于遗传病的遗传异质性和较大片段的基因，传统的Sanger测序技术已经远远不能满足医学研究及临床应用的需要。

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Conclusion A causative mutation of rhodopsin gene was identified in a large Chinese pedigree with ADRP. The present study confirmed the molecular genetic heterogeneity of ADRP.

结论在这个中国ADRP大家系中，发现RHO基因的致病突变，表明ADRP存在明显遗传异质性。

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Conclusion Haplotype and linkage analysis indicate that the Ashkenazi haplotypes is not associated with HMPS in Singapore Chinese families, which suggests genetic heterogeneity.

结论单倍型及遗传连锁分析提示，Ashkenazi单倍型与华人HMPS无关，两者存在遗传背景的差异性。

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TSC displays genetic heterogeneity with two known genes: TSC1 and TSC2, which was cloned in1997 and1993 respectively.

该病具有遗传异质性，致病基因包含TSC1基因和TSC2基因，分别于1997年和1993年被克隆出。

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Conclusion The mutation rate of TH gene in Chinese patients with AR-DRD is low, hence suggesting the genetic heterogeneity and a new locus for AR-DRD.

结论TH基因在中国人AR-DRD家系中突变率不高，提示我国AR-DRD患者具有遗传异质性，可能存在新的致病基因。

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Segregation analysis and consanguinity analysis were applied to 37 albinism families ascertained from Shandong province ( P.R.China) to study the genetic heterogeneity of the disease.

本文应用分离分析和血缘分析方法，对山东省100余万人群遗传病调查中发现的37个白化病核心家系进行了分析。

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Blood stasis syndrome pedigrees patients with non home show differences gene expression spectrum results, coronary heart disease with blood stasis syndrome essence may be genetic heterogeneity. 4.

冠心病血瘀证的家系和非家系患者的基因表达谱结果的差异表明，冠心病血瘀证的证本质可能存在遗传异质性。

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The expressivity of DSD, characterized by highly significant difference and high level of genetic heterogeneity, makes this severe disease difficult to classify and diagnosis.

该病具有表现度的显著差异性及高度遗传异质性，是一系列严重危害人类身心健康的难以归类、难以诊断的复杂性遗传病。

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Genetic heterogeneity and exclusion of a modifying locus at 2q in a family with autosomal dominant primary erythermalgia

常染色体显性遗传的原发性红斑性肢痛病家系的遗传异质性及排除定位于2q染色体的一个修饰位点

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Genetic heterogeneity, combined with phenotypic imprecision and poor marker coverage, has contributed to the difficulty in defining risk variants.

遗传异质性、表型介定的不精确性和标记覆盖的狭窄范围增加了定义风险变异的难度。

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Inflammation arises from a number of mutations of immunomodulatory molecules, supporting the concept of genetic heterogeneity for IBD.

炎症性肠病（IBD）具有遗传异质性，许多免疫调制分子基因的突变可导致炎症发生。

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Marie Unna hereditary hypotrichosis: Report of a Chinese family and evidence for genetic heterogeneity

Marie-Unna遗传性稀毛症：1例中国家族病例报道及其遗传学证据

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The clinical features of various types of MPS: MPS exhibited significant genetic heterogeneity and various degrees of multi-system injury.

各型MPS临床特点：MPS具有明显的遗传异质性，表现为不同程度的多系统损伤。

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Conclusion: Genetic heterogeneity is existed in the E2 region of HGV and decreased by IFN therapy.

结论：基因异质性存在于HGV的E2区，干扰素治疗可减少基因异质性。

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Essential hypertension is a complex disorder having high genetic heterogeneity, which is the result of interaction between nature and nurture.

原发性高血压是一种遗传与环境因素相互作用，具有很强遗传异质性的疾病。

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Genetic heterogeneity of expression of Ras gene in patients with non-small-cell lung cancer of Xuanwei and Kunming

云南宣威昆明两地肺癌ras基因表达的异质性研究

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Objective: To detect the genetic heterogeneity in E2 region of Hepatitis G Virus ( HGV).

目的：检测庚型肝炎病毒E2区的基因异质性。

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