The Duke scientists began their search for genes associated with the disease by studying two families whose members had hereditary spastic paraplegia.

Characteristics of Mutation of Disease-causing Genes in Chinese Patients Diagnosed as Hereditary Spastic Paraplegia and Its Relation to Clinical Phenotype

一个患有瘫痪症的病人。遗传性痉挛性截瘫患者致病基因突变特征及其与临床表型的关系

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A clinical, genetic and candidate gene study of Silver syndrome, a complicated form of hereditary spastic paraplegia

遗传性痉挛性截瘫的一种复杂表现形式：西尔弗综合征的临床、遗传学和候选基因研究

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Hereditary Spastic Paraplegia of 5 Cases

五例遗传性痉挛性截瘫

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A report 3 of cases with hereditary spastic paraplegia

遗传性痉挛性截瘫3例报告

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A novel locus for hereditary spastic paraplegia with thin corpus callosum and epilepsy

伴胼胝体发育不良和癫痫的遗传性痉挛性截瘫的一个新基因位点

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Conclusions The clinical characteristics in HSP cases are similar to familial history.

结论遗传性痉挛性截瘫散发病例的临床特点与有家族史者相似。

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Clinical characteristics of hereditary spastic paraplegia with thin corpus callosum

遗传性痉挛性截瘫伴薄型胼胝体的临床特征

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Genetic analysis for 19 cases of hereditary spastic paraplegia in a family

遗传性痉挛性截瘫一大家系19例遗传学分析

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Hereditary spastic paralegia: Diagnosis and analysis of 24 sporadic cases

遗传性痉挛性截瘫散发病例的诊断

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Aim: To explore the feature of hereditary spastic paraplegia with thin corpus callosum ( HSP-TCC) for the profound recognition of this disease.

目的：分析遗传性痉挛性截瘫伴胼胝体发育不良（HSP-TCC）的临床特点，以提高对此病的认识。

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Objective To explore the clinical characteristics of hereditary spastic paraplegia with thin corpus callosum ( HSP TCC).

目的探讨遗传性痉挛性截瘫伴薄型胼胝体（HSP TCC）的临床特征。

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Gene Mapping and Mutation Detection in Families with Hereditary Spastic Paraplegia

遗传性痉挛性截瘫家系的基因定位与突变检测

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Troyer syndrome revisited: A clinical and radiological study of a complicated hereditary spastic paraplegia

Troyer综合征回访：复杂遗传性痉挛性截瘫的临床和放射学研究

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Immunoenhancement on IBDV DNA vaccine by embryo vaccination with plasmid DNA encoding chicken interleukin-18

鸡胚接种鸡白介素18重组质粒对IBDV DNA疫苗免疫增强作用的研究

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Response of HBV DNA to HBV Vaccination Tested by PCR

PCR检测HBV DNA对乙肝疫苗应答反应的研究

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DNA vaccination is a technique to inoculate directly eukaryotic expression plasmid containing encoding antigenic gene into body and then the plasmid express the related antigen to produce an immunological response for protecting an organism against disease.

DNA疫苗是将含有编码抗原基因的真核表达质粒直接接种体内，在体内表达相应抗原，以刺激机体产生针对该抗原的免疫应答，产生保护性免疫。

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Objective To testify the effect of C3d molecular adjuvant on the immunogenicity of human chorionic gonadotropin β ( hCG β) DNA vaccination as well as the mode of immune response.

目的研究分子佐剂C3d能否增强人绒毛膜促性腺激素（hCG）βDNA疫苗的免疫原性，并转变Th1/Th2型免疫应答模式。

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Objective To investigate the effects of allergen-FC fusion DNA vaccination on airway inflammation and airway hyperreactivity ( AHR) in a murine asthma model.

目的探讨OVA-Fc融合基因疫苗治疗哮喘小鼠气道炎症和气道高反应性的效果。

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The successful cloning of important antigenic determinant-containing regions of pac gene is a significant preparation for the research of anti-caries DNA vaccination.

对含pac基因重要抗原决定簇区域的成功克隆为DNA免疫防龋研究完成了重要准备。

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Cytokines play key roles in the process of immune response and, the plasmid type of cytokine can modulate immune response in DNA vaccination.

细胞因子在免疫应答过程中具有重要的作用，编码细胞因子的质粒DNA可有效促进和调节DNA疫苗所诱导的免疫应答。

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