DNA methylation is an important epigenetic modification of the mammalian genome that regulates gene expression and chromatin organization.

1、

The discovery of the histone lysine demethylases has strongly demonstrated that histone lysine methylation is a reversible epigenetic modification.

组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰，在基因的表观遗传转录调控中起着关键的作用。

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On account of this, the molecular characterization and epigenetic regulation of genes, which are involved in fat metabolism, were studied in swine and chicken here.

基于此，以猪、鸡为研究对象，本试验对影响脂肪代谢相关基因的分子特征和表观遗传调控进行了研究。

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These data are proof of principle for cell-type specific epigenetic regulation in placenta and demonstrate that the methylation profile of placenta is mainly driven by cytotrophoblasts.

这些数据是胚胎中细胞类型特异表观遗传调控原理的证明，并证明胚胎的甲基化谱主要由细胞滋养细胞驱动。

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Histone methylation is an important component of epigenetic regulation, which can regulate gene expression and participate in a variety of biological processes.

组蛋白甲基化是表观遗传调控的一种重要方式，与基因的转录调控密切相关，参与多种生物进程。

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Our data suggest that epigenetic regulation of gene expression is likely to be a key factor in the functional specificity of cytotrophoblasts.

我们的数据表明基因表达的表观遗传调控可能是细胞滋养细胞功能特异性的一个关键因子。

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Histone posttranslational modifications and sequence variants jointly participate in modification of chromatin and regulation of gene expression.

组蛋白的变体和翻译后修饰共同参与染色质修饰和基因的表观遗传调控。

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These modifications regulate histone-DNA interactions, adding a new dimension to the epigenetic regulation of nucleosome mobility.

这些修饰调控组蛋白-DNA相互作用，为核小体迁移的表观遗传调控添加了新的维度。

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Here we've established a new role for SUMOylation, mediating the interaction between protein and protein methylation in epigenetic regulation.

在这里我们已经建立了SUMO结合的新角色，在表观遗传调控中调控的蛋白质和蛋白质甲基化。

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Methylation and demethylation of DNA are the complementary processes of epigenetic regulation. Methylation and demethylation influence a diverse array of cellular activities, including X chromosome inactivation, genomic imprinting, chromatin modification, and the silencing of endogenous genes.

DNA甲基化与去甲基化是表观遗传调控的两种重要调节方式，其在X染色体失活、基因组印迹、染色质修饰和内源性基因沉默等过程中发挥重要作用。

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Intrinsic DNA methylamine pattern is an integral component of the epigenetic network in many eukaryotes. Study on variation of DNA methylation pattern will help us a comprehensive understanding of function of DNA methylation on the apparent biological control.

内源DNA的甲基化是真核生物的表观遗传调控的重要组成部分，研究特定条件下DNA甲基化的变异模式有助于我们全面的理解DNA甲基化的表观调控生物学功能。

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Epigenetic Regulation of Multidrug Resistance Gene 1 and its Effect on Cervical Cancer

肿瘤MDR1基因表观遗传调控及其对宫颈癌的启示

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Understanding the dynamics of DNA methylation associated with development, and transmission genetics of methylation patterns across organismal generations are important facets for elucidating the roles played by epigenetic paradigms in plant development and genome evolution.

研究DNA甲基化在个体发育过程中的动态变化以及甲基化模式在世代之间的传递遗传学对于阐明DNA甲基化在植物发育过程中和基因组进化过程中的表观遗传调控作用具有重要意义。

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Purpose Previous study has confirmed that aberrant epigenetic modifications play important role in the occurrence and development of systemic lupus erythematosus ( SLE).

目的大量研究证实表观遗传调控异常在系统性红斑狼疮（Systemic lupus erythematosus，SLE）发病中发挥重要作用。

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These fragments encode proteins involved in electron transfer and proton transport, the ubiquitin-proteasome pathway, and epigenetic gene regulation.

这些基因编码蛋白参与电子和质子转运、泛素&蛋白体途径以及表观遗传调控（epigenetic regulation）等。

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Epigenetic Regulation of Tumor Suppressor Gene PTEN and Its Anticancer Mechanisms

肿瘤抑制基因PTEN的表观遗传调控及其抗肿瘤机制研究

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DNA methylation is a major component of the epigenetic regulation machinary in eukaryotes.

DNA的甲基化修饰是真核生物的表观遗传调控的重要组成部分。

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An epigenetic event alters the activity of genes without changing their structure.

表观遗传调控可以影响基因转录活性而不涉及DNA序列的改变。

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Transcription is a complex process that relies on the collective action of genetic and epigenetic regulation.

真核基因表达是一个高度复杂的过程，是遗传调控和表观遗传调控综合作用的结果。

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Epigenetic regulation for prevention and gene therapy of tumors

表观遗传调控与肿瘤疾病的防治

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They can be classified into as follow categories according to their putativefunctions: regulatory protein, transcription factor, protein biosynthesis, protein folding, assembly, proteolysis, defense reaction, energy metabolism, cytoskeleton, retrotransposon, metabolism, and unknown protein.

根据蛋白质的功能可以把他们划分为调控蛋白，转录因子，蛋白质合成，蛋白质折叠、装配、降解，防卫反应，能量代谢，细胞骨架，逆转录转座子，代谢酶，以及未知功能的蛋白质。

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