Purpose: The DNA double-strand breaks ( DSB) and its repair ability of human tumor cell lines after irradiation were detected for studying the correlation to cell radiosensitivity.

Studies on DNA DSB and its rejoining repair in a mutated radiosensitive mouse mammary cancer cell line, sx-9

小鼠乳癌细胞辐射敏感突变株SX-9DNA双链断裂及其重接修复研究

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Determinants of tumor radiosensitivity are the intrinsic sensitivity of tumor cells, which affected by the cellular DNA double-strand break ( DSB) repair capacity.

肿瘤放射敏感性的决定因素是肿瘤细胞内在敏感性，而影响细胞内在敏感性的最重要因素是细胞DNA双链断裂（DSB）修复能力。

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Deficiencies in cellular responses to DNA damage can predispose to cancer. Ionizing radiation can cause cluster damage and double-strand breaks ( DSBs) that pose problems for cellular repair processes.

细胞对DNA损伤反应缺陷会诱发肿瘤，电离辐射可引起DNA簇损伤和双链断裂，成为细胞修复过程的问题。

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It is reported that the gene at fragile site is susceptible to DNA double strand breaks and misrepair, so it could be the target of damage in mismatch repair deficient tumors.

有报道指出位于脆性位点的基因由于对DNA双链断裂及错误修复较为敏感，因而可能在错配修复缺陷肿瘤中成为损伤的靶目标。

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PFGE analysis of DNA double-strand breaks and DNA repair process in human osteosarcoma cells irra-diated by X-rays

应用脉冲电场凝胶电泳分析X射线诱发人骨肉瘤细胞DNA双链断裂与损伤修复效应

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Ku70/ Ku80 proteins are two regulatory subunits of the DNA-dependent protein kinase ( DNA-PK), which plays an essential role in repairing DNA double-strand breaks ( DSBs).

Ku70/Ku80是DNA依赖蛋白激酶（DNA-PK）的辅助亚基，DNA-PK在双链DNA断裂修复过程中起重要的作用。

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Conclusion The curve of DNA repair in vitro of human lymphocytes could be considered in biodosimetry estimation because the process of DNA re-pair in vitro could display the repair level and speed of DNA double-strand break in vivo.

结论人淋巴细胞离体辐照后的修复过程可基本反映体内DNA双链断裂的修复水平与速度，修复曲线可以作为辐射生物剂量估算时的参考。

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HIV-1 Tat protein sensitizes cells to ionizing radiation via, at least partially, depressing DNA-PKcs expression and DNA repair.

HIV-1Tat蛋白抑制DNA-PKcs的表达，降低DNA双链断裂的修复，使细胞的电离辐射敏感性增高。

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The efficiency and fidelity of rejoining of the DNA double strand break in the immunocytes of tonsils of irradiated mice

小鼠扁桃体免疫细胞受照射后DNA双链断裂损伤修复的忠实性

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Apart from DNA repair, non-homologous end joining ( NHEJ) may play a role in V ( D) J recombination, and integration of HIV-1 genome into a host genome, as well as the insertion of pseudogenes and repetitive sequences into the genome of mammalian cells.

非同源末端连接途径除了在DNA双链断裂修复中起重要作用外，在V（D）J重组、HIV-1病毒整合宿主基因，以及假基因和重复序列的插入上也起着重要作用。

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The NBS1 is a component of the MRE11/ RAD50/ NBS1 complex ( MRN) and plays a critical role in the DNA double strand break ( DSB) repair and the maintenance of chromosomal integrity.

NBS1作为MRE11/RAD50/NBS1复合物的组分之一，是细胞应答DNA损伤的一个关键蛋白质，在DNA双链断裂修复和维持基因组稳定中发挥重要的作用。

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Taken together, the findings reveal a central role of DNA-PKcs in hydroquinone hematotoxicity in which it coordinates pathways of DNA DSB repair, cell cycle progression, and apoptosis to regulate the response to hydroquinone-induced DNA damage.

该结果揭示了DNA-PKcs在氢醌血液毒性中的核心作用，它负责参与DNA双链断裂修复、细胞周期的进行和细胞凋亡的调节，以应对氢醌引起的K562细胞DNA损伤和细胞凋亡。

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Conclusion: Ku protein plays an important role in rejoining of DNA double stand breaks ( DSBs) induced by x-ray.

结论：Ku蛋白在放射引起DNA双链断裂修复、再连接中具有重要作用，Ku80蛋白缺乏细胞的DNA双链断裂后的重组修复能力的缺陷是固有的，并不因放射剂量的改变而不同。

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Association Study of the Polymorphism in DNA Double Strand Break Repair Gene and Gene Rearrangement in Papillary Thyroid Carcinoma

DNA双链断裂修复基因多态性与乳头状甲状腺癌基因重排的相关性分析

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Mammalian cells accomplish DSBs via two pathways: non-homologous end joining and homologous recombination.

哺乳动物细胞有两种重要的DNA双链断裂修复方式：非同源末端连接和同源重组。

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Repair Inhibition of DNA Double-strand Breaks and Radiosensitization

DNA双链断裂修复抑制与放射增敏

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CHAIN OF TESTS OF SERIES Conservation and Specificity of DNA Double-strand Break Repair in Plants

植物DNA双链断裂修复的保守性和特异性

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γ-ray dose rate effect in DNA double-strand break repair deficient murine cells

小鼠DNA双链断裂修复缺陷细胞的γ射线剂量率效应

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Be it cruel to confine a bird in a cage.

把鸟关在笼子里残忍不残忍.

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I will stop at no expense to obtain it.

我将不惜一切花费来得到它.

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